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Western Blot (WB) (Western blot analysis of ZIP8 in human spleen tissue lysate with ZIP8 antibody at (A) 1 and (B) 2 μg/mL.)

Rabbit anti-Human ZIP8 Polyclonal Antibody | anti-Slc39a8 antibody

ZIP8 Antibody

Gene Names
SLC39A8; ZIP8; PP3105; BIGM103; LZT-Hs6
Reactivity
Human
Applications
ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
Purity
ZIP8 Antibody is affinity chromatography purified via peptide column.
Synonyms
ZIP8; Polyclonal Antibody; ZIP8 Antibody; PP3105; BIGM103; LZT-Hs6; Zinc transporter ZIP8; BCG-induced integral membrane protein in monocyte clone 103 protein; solute carrier family 39 (zinc transporter); member 8; anti-Slc39a8 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
ZIP8 antibody is predicted to not cross-react with other ZIP family members.
Purity/Purification
ZIP8 Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (varies by lot)
Sequence Length
460
Applicable Applications for anti-Slc39a8 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes
ZIP8 antibody can be used for detection of ZIP8 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.
Conjugate
Unconjugated
Immunogen
ZIP8 antibody was raised against a 18 amino acid synthetic peptide near the carboxy terminus of human ZIP8.
Buffer
ZIP8 Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
ZIP8 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of ZIP8 in human spleen tissue lysate with ZIP8 antibody at (A) 1 and (B) 2 μg/mL.)

Western Blot (WB) (Western blot analysis of ZIP8 in human spleen tissue lysate with ZIP8 antibody at (A) 1 and (B) 2 μg/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of ZIP8 in human spleen tissue with ZIP8 antibody at 5 μg/mL.)

Immunohistochemistry (IHC) (Immunohistochemistry of ZIP8 in human spleen tissue with ZIP8 antibody at 5 μg/mL.)

Immunofluorescence (IF)

(Immunofluorescence of ZIP8 in human spleen tissue with ZIP8 antibody at 20 μg/mL.)

Immunofluorescence (IF) (Immunofluorescence of ZIP8 in human spleen tissue with ZIP8 antibody at 20 μg/mL.)
Related Product Information for anti-Slc39a8 antibody
ZIP8 Antibody: The zinc transporter ZIP8, also known as SLC39A9, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. The zinc transporter family is divided into four subfamilies (I, II, LIV-1 and gufA). ZIP8 is glycosylated and located at the plasma membrane and mitochondria. It has been identified as the transporter responsible for transport of the toxic Cadmium cation. ZIP8 has also been suggested to play a role in the regulation of interferon-gamma expression in activated human T cells.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
48,089 Da
NCBI Official Full Name
zinc transporter ZIP8 isoform a
NCBI Official Synonym Full Names
solute carrier family 39 (zinc transporter), member 8
NCBI Official Symbol
SLC39A8
NCBI Official Synonym Symbols
ZIP8; PP3105; BIGM103; LZT-Hs6
NCBI Protein Information
zinc transporter ZIP8; ZIP-8; Zrt- and Irt-like protein 8; solute carrier family 39 member 8; LIV-1 subfamily of ZIP zinc transporter 6; BCG induced integral membrane protein BIGM103; solute carrier family 39 (metal ion transporter), member 8; BCG-induced integral membrane protein in monocyte clone 103 protein
UniProt Protein Name
Zinc transporter ZIP8
Protein Family
UniProt Gene Name
SLC39A8
UniProt Synonym Gene Names
BIGM103; ZIP8; LZT-Hs6; ZIP-8
UniProt Entry Name
S39A8_HUMAN

NCBI Description

This gene encodes a member of the SLC39 family of solute-carrier genes, which show structural characteristics of zinc transporters. The encoded protein is glycosylated and found in the plasma membrane and mitochondria, and functions in the cellular import of zinc at the onset of inflammation. It is also thought to be the primary transporter of the toxic cation cadmium, which is found in cigarette smoke. Multiple transcript variants encoding different isoforms have been found for this gene. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Oct 2008]

Uniprot Description

SLC39A8: Acts as a zinc-influx transporter. Belongs to the ZIP transporter (TC 2.A.5) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Transporter, SLC family; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 4q24

Cellular Component: plasma membrane; integral to membrane

Molecular Function: metal ion transmembrane transporter activity

Biological Process: zinc ion transport; transmembrane transport

Research Articles on Slc39a8

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Product Notes

The Slc39a8 slc39a8 (Catalog #AAA151012) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ZIP8 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ZIP8 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). ZIP8 antibody can be used for detection of ZIP8 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL. Researchers should empirically determine the suitability of the Slc39a8 slc39a8 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ZIP8, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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