Rabbit anti-Human ZGPAT Polyclonal Antibody | anti-ZGPAT antibody

ZGPAT Polyclonal Antibody

Cat. Num. AAA2562552

• Gene Names: ZGPAT; ZIP; ZC3H9; GPATC6; GPATCH6; ZC3HDC9; KIAA1847
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA
• Purity: Antigen Affinity Purification
• Synonyms: ZGPAT; Polyclonal Antibody; ZGPAT Polyclonal Antibody; dJ583P15.3; FLJ14972; G patch domain-containing protein 6; GPATC6; GPATCH6; KIAA1847; MGC44880; RP4 583P15.3; ZC3H9; ZC3HDC9; Zinc finger and G patch domain-containing protein; Zinc finger CCCH domain-containing protein 9; Zinc finger CCCH type with G patch domain1; Zinc finger CCCH-type with G patch domain-containing protein; ZIP; anti-ZGPAT antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purification
• Form/Format: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
• Concentration: 0.6mg/mL (varies by lot)
• Sequence Length: 531

• Applicable Applications for anti-ZGPAT antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:40-1:200; ELISA: 1:5000-1:10000
• Immunogen: Fusion protein of human ZGPAT
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using ZGPAT Polyclonal Antibody at dilution of 1:35(×200))

Related Product Information for anti-ZGPAT antibody

ZGPAT (Zinc finger CCCH-type with G patch domain-containing protein), also known as zinc finger CCCH domain-containing protein 9 (ZC3HDC9) and G patch domain-containing protein 6 (GPATC6), is a 531 amino acid protein that contains a G-patch domain, which is typically found within RNA-binding proteins. Proteins that contain the G-patch domain include some tumor suppressor and DNA-damage repair proteins. ZGPAT also contains one C3H1-type zinc finger, which further supports its probable role as an RNA-binding protein. The gene encoding ZGPAT is inactivated via differential methylation in a oligodendroglioma cell line, suggesting that ZGPAT may have utility as a biomarker. There are two isoforms of ZGPAT that are produced as a result of alternative splicing events.

Product Categories/Family for anti-ZGPAT antibody

Epigenetics and Nuclear Signaling

NCBI and Uniprot Product Information

• NCBI GI #: 133925793
• NCBI GeneID: 84619
• NCBI Accession #: NP_115916; BC019338
• NCBI GenBank Nucleotide #: NP_115916.3
• UniProt Accession #: Q8N5A5
• NCBI Official Full Name: zinc finger CCCH-type with G patch domain-containing protein isoform a
• NCBI Official Synonym Full Names: zinc finger CCCH-type and G-patch domain containing
• NCBI Official Symbol: ZGPAT
• NCBI Official Synonym Symbols: ZIP; ZC3H9; GPATC6; GPATCH6; ZC3HDC9; KIAA1847
• NCBI Protein Information: zinc finger CCCH-type with G patch domain-containing protein
• UniProt Protein Name: Zinc finger CCCH-type with G patch domain-containing protein
• UniProt Gene Name: ZGPAT
• UniProt Synonym Gene Names: GPATC6; GPATCH6; KIAA1847; ZC3H9; ZC3HDC9; ZIP
• UniProt Entry Name: ZGPAT_HUMAN

Uniprot Description

ZGPAT: Transcription repressor that specifically binds the 5'- GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 20q13.3

Cellular Component: nucleus

Molecular Function: protein binding; sequence-specific DNA binding; metal ion binding; transcription factor activity

Biological Process: negative regulation of epidermal growth factor receptor activity; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent