Western Blot (WB)
(Western blot analysis of extracts from HT-29 cells, using ZFYVE19 antibody.)
Rabbit anti-Human ZFYVE19 Polyclonal Antibody | anti-ZFYVE19 antibody
ZFYVE19 Antibody
Gene Names
ZFYVE19; ANCHR; MPFYVE
Reactivity
Human
Applications
Western Blot, Immunohistochemistry
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Synonyms
ZFYVE19; Polyclonal Antibody; ZFYVE19 Antibody; MLL partner containing FYVE domain; MPFYVE; ZFY19; Zinc finger FYVE domain-containing protein 19; anti-ZFYVE19 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Specificity
The antibody detects endogenous levels of total ZFYVE19 protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0 mg/ml (varies by lot)
Sequence Length
471
Applicable Applications for anti-ZFYVE19 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Immunohistochemistry: 1:50~1:100
Immunogen Type
Peptide
Immunogen Description
Synthesized peptide derived from internal of human ZFYVE19.
Target Name
ZFYVE19
Preparation and Storage
Store at -20 degree C
Western Blot (WB)
(Western blot analysis of extracts from HT-29 cells, using ZFYVE19 antibody.)
Western Blot (WB)
(Western blot analysis of extracts from HT-29 cells, using ZFYVE19 antibody.)
Immunohistochemistry (IHC)
(Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using ZFYVE19 antibody.)
Immunohistochemistry (IHC)
(Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using ZFYVE19 antibody.)
Related Product Information for anti-ZFYVE19 antibody
Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.Chinwalla V., Oncogene 22:1400-1410(2003).Ota T., Nat. Genet. 36:40-45(2004).The MGC Project Team, Genome Res. 14:2121-2127(2004).
Product Categories/Family for anti-ZFYVE19 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
32,963 Da
NCBI Official Full Name
abscission/NoCut checkpoint regulator isoform 1
NCBI Official Synonym Full Names
zinc finger, FYVE domain containing 19
NCBI Official Symbol
ZFYVE19
NCBI Official Synonym Symbols
ANCHR; MPFYVE
NCBI Protein Information
abscission/NoCut checkpoint regulator
UniProt Protein Name
Abscission/NoCut checkpoint regulator
Protein Family
UniProt Gene Name
ZFYVE19
UniProt Synonym Gene Names
ANCHR; MPFYVE; ANCHR
UniProt Entry Name
ANCHR_HUMAN
Uniprot Description
ZFYVE19: A chromosomal aberration involving ZFYVE19 is associated with acute myeloblastic leukemia (AML). Translocation t(11;15)(q23;q14) with MLL/HRX. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Oncoprotein
Chromosomal Location of Human Ortholog: 15q15.1
Cellular Component: centrosome; cytoplasm; midbody; cleavage furrow
Molecular Function: protein binding; zinc ion binding; phosphatidylinositol 3-phosphate binding
Biological Process: cell division; abscission; cell cycle; negative regulation of cytokinesis
Research Articles on ZFYVE19
Similar Products
Product Notes
The ZFYVE19 zfyve19 (Catalog #AAA9405118) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ZFYVE19 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ZFYVE19 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Western blotting: 1:500~1:3000 Immunohistochemistry: 1:50~1:100. Researchers should empirically determine the suitability of the ZFYVE19 zfyve19 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ZFYVE19, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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