Rabbit ZBTB7A Polyclonal Antibody | anti-ZBTB7A antibody

ZBTB7A Polyclonal Antibody

Cat. Num. AAA3006977

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: ZBTB7A; Polyclonal Antibody; ZBTB7A Polyclonal Antibody; Zinc finger and BTB domain-containing protein 7A; Factor binding IST protein 1; FBI-1; Factor that binds to inducer of short transcripts protein 1; HIV-1 1st-binding protein 1; Leukemia/lymphoma-related factor; POZ and Krueppel erythroid myeloid ontogenic factor; POK erythroid myeloid ontogenic factor; Pokemon; TTF-I-interacting peptide 21; TIP21; Zinc finger protein 857A; FBI1; LRF; ZBTB7; ZNF857A; anti-ZBTB7A antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: ZBTB7A polyclonal antibody detects endogenous levels of ZBTB7A protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 584

• Applicable Applications for anti-ZBTB7A antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to residues in Human ZBTB7A
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of ZBTB7A polyclonal antibody at 1:500 dilutionLane1:A549 whole cell lysateLane2:sp2/0 whole cell lysate Lane3:PC12 whole cell lysate)

Related Product Information for anti-ZBTB7A antibody

LRF, formerly identified as Pokemon, is a poxvirus zinc finger (POZ) domain-containing transcription factor that influences cell differentiation. LRF (for leukemia/lymphoma related factor) is also known as zinc finger and BTB domain containing 7A, ZBTB7, TIP21, FBI1 and FBI-1. POZ-domain transcription factors contain a POZ or BTB type protein-protein interaction domain at their N-terminus and Kruppel-type zinc fingers at their C-terminus. LRF is inducible during both murine and human preadipocyte differentiation and may contrib-ute to adipogenesis through influencing the switch from cellular proliferation to terminal differentiation. LRF can associate with active chromatin and stimulate TAT-activated HIV-1 transcription through interactions with the HIV-1 long terminal repeat. 3T3L1 cells stably overexpressing LRF show a reduction in DNA synthesis and in expression of cyclin A, cyclin-dependent kinase 2 and p107.

NCBI and Uniprot Product Information

• NCBI GI #: 578833301
• NCBI Accession #: XP_005259627.2
• NCBI GenBank Nucleotide #: XP_005259627.2
• UniProt Accession #: O95365
• Molecular Weight: ~ 61kDa
• NCBI Official Full Name: zinc finger and BTB domain-containing protein 7A isoform X1
• UniProt Protein Name: Zinc finger and BTB domain-containing protein 7A
• Protein Family: Zinc finger and BTB domain-containing protein
• UniProt Gene Name: ZBTB7A
• UniProt Synonym Gene Names: FBI1; LRF; ZBTB7; ZNF857A; FBI-1; POK erythroid myeloid ontogenic factor; Pokemon; TIP21
• UniProt Entry Name: ZBT7A_HUMAN

Uniprot Description

FBI1: a widely expressed zinc finger protein. Apparently interacts with Bcl-6.

Protein type: DNA-binding; Transcription factor; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: nucleus

Molecular Function: histone acetyltransferase binding; protein binding; DNA binding; metal ion binding

Biological Process: transcription, DNA-dependent; multicellular organismal development; negative regulation of transcription from RNA polymerase II promoter; cell differentiation; negative regulation of transcription, DNA-dependent