Rabbit anti-Human ZBTB16 Polyclonal Antibody | anti-ZBTB16 antibody

ZBTB16, CT (Zinc Finger And BTB Domain-containing Protein 16, Zinc Finger Protein PLZF, Promyelocytic Leukemia Zinc Finger Protein, Zinc Finger Protein 145, ZBTB16, PLZF, ZNF145)

Cat. Num. AAA627254

• Gene Names: ZBTB16; PLZF; ZNF145
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Purified; Purified by ammonium sulfate precipitation.
• Synonyms: ZBTB16; Polyclonal Antibody; CT (Zinc Finger And BTB Domain-containing Protein 16; Zinc Finger Protein PLZF; Promyelocytic Leukemia Zinc Finger Protein; Zinc Finger Protein 145; PLZF; ZNF145); Anti -ZBTB16; anti-ZBTB16 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human PLZF.
• Purity/Purification: Purified; Purified by ammonium sulfate precipitation.
• Form/Format: Supplied as a liquid in PBS, 0.09% sodium azide.

• Applicable Applications for anti-ZBTB16 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: ELISA: 1:1,000; Western Blot: 1:50-1:100
• Immunogen: Synthetic peptide selected from the C-terminal region of human PLZF (KLH).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-ZBTB16 antibody

PLZF is a member of the Krueppel C2H2-type zinc-finger protein family and a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL).

Product Categories/Family for anti-ZBTB16 antibody

Antibodies; Abs to Transcription Factors; Zinc (Ring) Finger

NCBI and Uniprot Product Information

• NCBI GI #: 66932932
• NCBI GeneID: 7704
• NCBI Accession #: NP_001018011.1
• NCBI GenBank Nucleotide #: NM_001018011.1
• UniProt Accession #: Q05516; Q8TAL4; Q59H43; Q71UL5; Q71UL6; Q71UL7
• Molecular Weight: 74,274 Da
• NCBI Official Full Name: zinc finger and BTB domain-containing protein 16
• NCBI Official Synonym Full Names: zinc finger and BTB domain containing 16
• NCBI Official Symbol: ZBTB16
• NCBI Official Synonym Symbols: PLZF; ZNF145
• NCBI Protein Information: zinc finger and BTB domain-containing protein 16; OTTHUMP00000238379; OTTHUMP00000238382; zinc finger protein PLZF; zinc finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia)
• UniProt Protein Name: Zinc finger and BTB domain-containing protein 16
• Protein Family: Zinc finger and BTB domain-containing protein
• UniProt Gene Name: ZBTB16
• UniProt Synonym Gene Names: PLZF; ZNF145
• UniProt Entry Name: ZBT16_HUMAN

NCBI Description

This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq]

Uniprot Description

PLZF: Probable transcription factor. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Defects in ZBTB16 are the cause of skeletal defects genital hypoplasia and mental retardation (SGYMR). A disorder characterized by mental retardation, craniofacial dysmorphism, microcephaly and short stature. Additional features include absence of the thumbs, hypoplasia of the radii and ulnae, additional vertebrae and ribs, retarded bone age and genital hypoplasia. A chromosomal aberration involving ZBTB16 may be a cause of acute promyelocytic leukemia (APL). Translocation t(11;17)(q32;q21) with RARA. Belongs to the krueppel C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor; C2H2-type zinc finger protein; Oncoprotein; DNA-binding

Chromosomal Location of Human Ortholog: 11q23.1

Cellular Component: nuclear body; PML body; transcriptional repressor complex; plasma membrane; nucleolus; nuclear speck; cytosol; nucleus

Molecular Function: protein C-terminus binding; identical protein binding; protein domain specific binding; protein binding; protein homodimerization activity; DNA binding; metal ion binding; double-stranded DNA binding

Biological Process: negative regulation of myeloid cell differentiation; central nervous system development; transcription, DNA-dependent; apoptosis; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; protein ubiquitination; negative regulation of transcription from RNA polymerase II promoter; embryonic pattern specification; embryonic hindlimb morphogenesis; positive regulation of ossification; forelimb morphogenesis; anterior/posterior pattern formation; negative regulation of cell proliferation; positive regulation of chondrocyte differentiation; cartilage development; positive regulation of fat cell differentiation; mesonephros development; myeloid cell differentiation; hemopoiesis; positive regulation of NK T cell differentiation; embryonic digit morphogenesis; negative regulation of transcription, DNA-dependent; male germ-line stem cell division

Disease: Skeletal Defects, Genital Hypoplasia, And Mental Retardation