Western Blot (WB)
(Western blot analysis of PLZF Antibody (C-term) in 293, K562 cell line lysates (35ug/lane). PLZF (arrow) was detected using the purified Pab.)
Rabbit anti-Human PLZF Polyclonal Antibody | anti-ZBTB16 antibody
PLZF Antibody (C-term)
Western Blot (WB)
(Western blot analysis of PLZF Antibody (C-term) in 293, K562 cell line lysates (35ug/lane). PLZF (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of PLZF Antibody (C-term) in 293, K562 cell line lysates (35ug/lane). PLZF (arrow) was detected using the purified Pab.)
Doulatov,S., Genes Dev. 23 (17), 2076-2087 (2009)
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
Uniprot Description
PLZF: Probable transcription factor. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Defects in ZBTB16 are the cause of skeletal defects genital hypoplasia and mental retardation (SGYMR). A disorder characterized by mental retardation, craniofacial dysmorphism, microcephaly and short stature. Additional features include absence of the thumbs, hypoplasia of the radii and ulnae, additional vertebrae and ribs, retarded bone age and genital hypoplasia. A chromosomal aberration involving ZBTB16 may be a cause of acute promyelocytic leukemia (APL). Translocation t(11;17)(q32;q21) with RARA. Belongs to the krueppel C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Oncoprotein; C2H2-type zinc finger protein; DNA-binding; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 11q23.1
Cellular Component: nuclear body; PML body; transcriptional repressor complex; nucleolus; plasma membrane; nuclear speck; cytosol; nucleus
Molecular Function: protein C-terminus binding; protein domain specific binding; identical protein binding; protein binding; protein homodimerization activity; DNA binding; metal ion binding; double-stranded DNA binding
Biological Process: negative regulation of myeloid cell differentiation; central nervous system development; transcription, DNA-dependent; positive regulation of apoptosis; apoptosis; positive regulation of transcription, DNA-dependent; protein ubiquitination; negative regulation of transcription from RNA polymerase II promoter; embryonic pattern specification; embryonic hindlimb morphogenesis; positive regulation of ossification; forelimb morphogenesis; anterior/posterior pattern formation; negative regulation of cell proliferation; positive regulation of chondrocyte differentiation; cartilage development; positive regulation of fat cell differentiation; positive regulation of NK T cell differentiation; hemopoiesis; myeloid cell differentiation; mesonephros development; embryonic digit morphogenesis; male germ-line stem cell division; negative regulation of transcription, DNA-dependent
Disease: Skeletal Defects, Genital Hypoplasia, And Mental Retardation
Research Articles on ZBTB16
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Product Notes
The ZBTB16 zbtb16 (Catalog #AAA9208211) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 637-666. The PLZF Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PLZF can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the ZBTB16 zbtb16 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PLZF, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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