Rabbit anti-Human ZBP1 Polyclonal Antibody | anti-ZBP1 antibody

ZBP1 Rabbit pAb

Cat. Num. AAA4758217

• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity purified
• Synonyms: ZBP1; Polyclonal Antibody; ZBP1 Rabbit pAb; DAI; DLM1; DLM-1; C20orf183; anti-ZBP1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Purity/Purification: Affinity purified
• Form/Format: -20 degree C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

• Applicable Applications for anti-ZBP1 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: Synthetic peptide of human ZBP1
• Conjugation: Unconjugated
• Molecular Function: This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
• Modification: Unmodified
• Preparation and Storage: Store at 4 degree C for short term. Store at -20 degree C for long term. Avoid freeze/thaw cycle.

Western Blot (WB)

(Gel: 10%SDS-PAGE, Lysate: 40 ug, Lane: Raji cells, Primary antibody: 856002(ZBP1 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds)

Product Categories/Family for anti-ZBP1 antibody

Primary antibody

NCBI and Uniprot Product Information

• UniProt Accession #: Q9H171
• Molecular Weight: 46kDa
• UniProt Protein Name: Z-DNA-binding protein 1
• Protein Family: Z-DNA-binding protein
• UniProt Gene Name: ZBP1
• UniProt Synonym Gene Names: C20orf183; DLM1
• UniProt Entry Name: ZBP1_HUMAN

Uniprot Description

ZBP1: Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 20q13.31

Cellular Component: cytoplasm; nucleus; cytosol

Molecular Function: double-stranded RNA adenosine deaminase activity; protein binding; DNA binding; left-handed Z-DNA binding; RNA binding

Biological Process: metabolic process; positive regulation of interferon type I production; innate immune response