Rabbit YWHAH Polyclonal Antibody | anti-YWHAH antibody

YWHAH antibody

Cat. Num. AAA5302860

• Gene Names: YWHAH; YWHA1
• Applications: Immunohistochemistry, Western Blot
• Synonyms: YWHAH; Polyclonal Antibody; YWHAH antibody; Polyclonal YWHAH; Anti-YWHAH; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein; eta polypeptide; YWHA1; anti-YWHAH antibody

• Host: Rabbit
• Clonality: Polyclonal
• Form/Format: Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 246

• Applicable Applications for anti-YWHAH antibody: Immunohistochemistry (IHC), Western Blot (WB)
• Application Notes: WB: 0.2-1 ug/ml
• Biological Significance: The YWHAH gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat has been associated with early-onset schizophrenia.
• Cross-Reactivity: Human, Mouse, Rat, Chicken, Bovine, Rabbit, African Clawed Frog
• Immunogen: YWHAH antibody was raised in rabbit using the N terminal of YWHAH as the immunogen
• Preparation and Storage: Store at 4 degree C, following reconstitution, aliquot and store at -20 degree C. Avoid repeated freeze-thaw cycles.

Western Blot (WB)

(YWHAH antibody (MBS5302860) used at 0.2-1 ug/ml to detect target protein.)

Related Product Information for anti-YWHAH antibody

Affinity purified rabbit polyclonal YWHAH antibody

Product Categories/Family for anti-YWHAH antibody

Neuroscience; Purified Polyclonal Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 47678755
• NCBI GeneID: 7533
• UniProt Accession #: Q04917
• Molecular Weight: 28,219 Da
• NCBI Official Full Name: YWHAH
• NCBI Official Synonym Full Names: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
• NCBI Official Symbol: YWHAH
• NCBI Official Synonym Symbols: YWHA1
• NCBI Protein Information: 14-3-3 protein eta
• UniProt Protein Name: 14-3-3 protein eta
• Protein Family: 14-3-3 protein
• UniProt Gene Name: YWHAH
• UniProt Synonym Gene Names: YWHA1
• UniProt Entry Name: 1433F_HUMAN

NCBI Description

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009]

Uniprot Description

14-3-3 eta: a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes.

Protein type: Nuclear receptor co-regulator; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 22q12.3

Cellular Component: cytoplasmic vesicle membrane; cytoplasm; plasma membrane; cytosol

Molecular Function: insulin-like growth factor receptor binding; protein domain specific binding; protein binding; enzyme binding; sodium channel regulator activity; protein heterodimerization activity; actin binding; glucocorticoid receptor binding

Biological Process: intracellular protein transport; substantia nigra development; apoptosis; regulation of neuron differentiation; glucocorticoid receptor signaling pathway; positive regulation of transcription, DNA-dependent; regulation of synaptic plasticity; glucocorticoid catabolic process; negative regulation of dendrite morphogenesis; regulation of sodium ion transport