Rabbit anti-Human YLAT2 Polyclonal Antibody | anti-YLAT2 antibody

YLAT2, CT (SLC7A6, KIAA0245, Y+L amino acid transporter 2, Cationic amino acid transporter, y+ system, Solute carrier family 7 member 6, y(+)L-type amino acid transporter 2) (APC)

Cat. Num. AAA6364315

• Gene Names: SLC7A6; LAT3; LAT-2; y+LAT-2
• Reactivity: Human
• Applications: Flow Cytometry, Functional Assay, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: YLAT2; Polyclonal Antibody; CT (SLC7A6; KIAA0245; Y+L amino acid transporter 2; Cationic amino acid transporter; y+ system; Solute carrier family 7 member 6; y(+)L-type amino acid transporter 2) (APC); SLC7A6; y(+)L-type amino acid transporter 2; anti-YLAT2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-YLAT2 antibody: Flow Cytometry (FC/FACS), FLISA, Western Blot (WB)
• Application Notes: FC/FACS: 1:10-50; FLISA: 1:1,000; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: YLAT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human YLAT2.
• Conjugate: APC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western blot analysis of YLAT2 Antibody (C-term) in HepG2 cell line lysates (35ug/lane).YLAT2 (arrow) was detected using the purified Pab.)

Flow Cytometry (FC/FACS)

(YLAT2 Antibody (C-term) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)

Related Product Information for anti-YLAT2 antibody

This protein involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. It requires co-expression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. It also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. It plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. It involved in the transport of L-arginine in monocytes and reduces uptake of ornithine in retinal pigment epithelial (RPE) cells.

Product Categories/Family for anti-YLAT2 antibody

Antibodies; Transport Proteins

References

Sekine, Y., et al. J. Am. Soc. Nephrol. 20(7):1586-1596(2009). Broer, S. Physiol. Rev. 88(1):249-286(2008). Xu, D., et al. Mol. Cell Proteomics 4(8):1061-1071(2005).

NCBI and Uniprot Product Information

• NCBI GI #: 115648022
• NCBI GeneID: 9057
• NCBI Accession #: NP_003974.3
• NCBI GenBank Nucleotide #: NM_003983.5
• UniProt Accession #: Q92536; Q68DS4; Q7L1N3
• Molecular Weight: 56.8kDa
• NCBI Official Full Name: Y+L amino acid transporter 2
• NCBI Official Synonym Full Names: solute carrier family 7 member 6
• NCBI Official Symbol: SLC7A6
• NCBI Official Synonym Symbols: LAT3; LAT-2; y+LAT-2
• NCBI Protein Information: Y+L amino acid transporter 2
• UniProt Protein Name: Y+L amino acid transporter 2
• UniProt Gene Name: SLC7A6
• UniProt Synonym Gene Names: Y+LAT2; y+LAT-2

Uniprot Description

Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells.