Western Blot (WB)
(Western blot analysis of anti-XTP3TPA Antibody (N-term) in HepG2 cell line lysates (35ug/lane). XTP3TPA(arrow) was detected using the purified Pab.)
Rabbit anti-Human XTP3TPA Polyclonal Antibody | anti-XTP3TPA antibody
XTP3TPA, NT (dCTP Pyrophosphatase 1, Deoxycytidine-triphosphatase 1, dCTPase 1, RS21C6, XTP3-transactivated Gene A Protein, DCTPP1, CDA03) (APC)
ELISA: 1:1,000
WB: 1:50-1:100
Applications are based on unconjugated antibody.
Western Blot (WB)
(Western blot analysis of anti-XTP3TPA Antibody (N-term) in HepG2 cell line lysates (35ug/lane). XTP3TPA(arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of anti-XTP3TPA Antibody (N-term) in HepG2 cell line lysates (35ug/lane). XTP3TPA(arrow) was detected using the purified Pab.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with XTP3TPA antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with XTP3TPA antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is dCTP pyrophosphatase, which converts dCTP to dCMP and inorganic pyrophosphate. The encoded protein also displays weak activity against dTTP and dATP, but none against dGTP. This protein may be responsible for eliminating excess dCTP after DNA synthesis and may prevent overmethylation of CpG islands. Three transcript variants, one protein-coding and the other two non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015]
Uniprot Description
XTP3TPA: Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for modified dCTP. Activity is highest with 5-iodo-dCTP, followed by 5-bromo-dCTP, unmodified dCTP, 5-methyl-dCTP and 5-chloro-dCTP. Hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has even lower activity with unmodified dATP, dTTP and dUTP (in vitro). Does not hydrolyze ATP, UTP, ITP, GTP, dADP, dCDP or dGTP. May protect DNA or RNA against the incorporation of non- canonical nucleotide triphosphates. May protect cells against inappropriate methylation of CpG islands by DNA methyltransferases.
Protein type: EC 3.6.1.12
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: cytosol
Molecular Function: dCTP diphosphatase activity; pyrimidine deoxyribonucleotide binding; magnesium ion binding; nucleoside-triphosphate diphosphatase activity
Biological Process: nucleoside triphosphate catabolic process; protein homotetramerization
Research Articles on XTP3TPA
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Product Notes
The XTP3TPA dctpp1 (Catalog #AAA6506302) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The XTP3TPA, NT (dCTP Pyrophosphatase 1, Deoxycytidine-triphosphatase 1, dCTPase 1, RS21C6, XTP3-transactivated Gene A Protein, DCTPP1, CDA03) (APC) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's XTP3TPA can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB). IHC: 1:10-1:50 ELISA: 1:1,000 WB: 1:50-1:100 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the XTP3TPA dctpp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "XTP3TPA, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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