Western Blot (WB)
(XRN2 Antibody (N-term) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the XRN2 antibody detected the XRN2 protein (arrow).)
Rabbit anti-Human XRN2 Polyclonal Antibody | anti-XRN2 antibody
XRN2, NT (XRN2, 5'-3' exoribonuclease 2, DHM1-like protein)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Western Blot (WB)
(XRN2 Antibody (N-term) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the XRN2 antibody detected the XRN2 protein (arrow).)
Western Blot (WB)
(XRN2 Antibody (N-term) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the XRN2 antibody detected the XRN2 protein (arrow).)
NCBI and Uniprot Product Information
NCBI Description
This gene shares similarity with the mouse Dhm1 and the yeast dhp1 gene. The yeast gene is involved in homologous recombination and RNA metabolism, such as RNA synthesis and RNA trafficking. Complementation studies show that Dhm1 has a similar function in mouse as dhp1. The function of the human gene has not yet been determined. Transcript variants encoding different isoforms have been noted for this gene; however, their full-length nature is not known. [provided by RefSeq, Jul 2008]
Uniprot Description
XRN2: Possesses 5'->3' exoribonuclease activity. May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: RNA-binding; RNA processing; Nucleolus; Cell development/differentiation; EC 3.1.13.-; Ribonuclease
Chromosomal Location of Human Ortholog: 20p11.2-p11.1
Cellular Component: membrane; nucleolus; nucleus
Molecular Function: 5'-3' exonuclease activity; 5'-3' exoribonuclease activity; nuclease activity; zinc ion binding
Biological Process: RNA processing; regulation of transcription, DNA-dependent; RNA metabolic process; RNA catabolic process; spermatogenesis; DNA catabolic process, exonucleolytic; mRNA processing; cell growth; transcription termination
Research Articles on XRN2
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Product Notes
The XRN2 xrn2 (Catalog #AAA645421) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The XRN2, NT (XRN2, 5'-3' exoribonuclease 2, DHM1-like protein) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's XRN2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in Western Blot, ELISA Dilution: ELISA: 1:1,000 Western Blot: 1:100-500. Researchers should empirically determine the suitability of the XRN2 xrn2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "XRN2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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