XPA Polyclonal Antibody | anti-XPA antibody

XPA Polyclonal Antibody

Cat. Num. AAA8525895

• Gene Names: XPA; XP1; XPAC
• Synonyms: XPA; Polyclonal Antibody; XPA Polyclonal Antibody; anti-XPA antibody

• Clonality: Polyclonal
• Sequence Length: 273

NCBI and Uniprot Product Information

• NCBI GI #: 4507937
• NCBI GeneID: 7507
• NCBI Accession #: NP_000371.1
• NCBI GenBank Nucleotide #: NM_000380.3
• UniProt Accession #: P23025; Q5T1U9; Q6LCW7; Q6LD02
• Molecular Weight: 31,368 Da
• NCBI Official Full Name: DNA repair protein complementing XP-A cells isoform 1
• NCBI Official Synonym Full Names: XPA, DNA damage recognition and repair factor
• NCBI Official Symbol: XPA
• NCBI Official Synonym Symbols: XP1; XPAC
• NCBI Protein Information: DNA repair protein complementing XP-A cells
• UniProt Protein Name: DNA repair protein complementing XP-A cells
• Protein Family: DNA repair protein
• UniProt Gene Name: XPA
• UniProt Synonym Gene Names: XPAC

NCBI Description

This gene encodes a zinc finger protein plays a central role in nucleotide excision repair (NER), a specialized type of DNA repair. NER is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens and chemotherapeutic drugs. The encoded protein interacts with DNA and several NER proteins, acting as a scaffold to assemble the NER incision complex at sites of DNA damage. Mutations in this gene cause Xeroderma pigmentosum complementation group A (XP-A), an autosomal recessive skin disorder featuring hypersensitivity to sunlight and increased risk for skin cancer. [provided by RefSeq, Aug 2017]

Uniprot Description

Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.