Rabbit anti-Human XK Polyclonal Antibody | anti-XK antibody

XK, NT (XK, XKR1, XRG1, Membrane transport protein XK, Kell complex 37kD component, Kx antigen, XK-related protein 1) (AP)

Cat. Num. AAA6363951

• Gene Names: XK; KX; NA; NAC; X1k; XKR1; MCLDS
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A and Peptide Affinity Chromatography.
• Synonyms: XK; Polyclonal Antibody; NT (XK; XKR1; XRG1; Membrane transport protein XK; Kell complex 37kD component; Kx antigen; XK-related protein 1) (AP); XK-related protein 1; anti-XK antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human XK.
• Purity/Purification: Purified by Protein A and Peptide Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

• Applicable Applications for anti-XK antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 83-111 in the N-terminal region of human XK. Swiss/UniProt Accession: P51811. Species sequence homology: mouse, rat
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in A549 cell line lysates (35ug/lane) usingMBS6012511. This demonstrates that MBS6012511 detected the XK protein (arrow).)

Related Product Information for anti-XK antibody

This locus controls the synthesis of the Kell blood group 'precursor substance' (Kx). Mutations in this gene have been associated with McLeod syndrome, an X-linked, recessive disorder characterized by abnormalities in the neuromuscular and hematopoietic systems. The encoded protein has structural characteristics of prokaryotic and eukaryotic membrane transport proteins.

Product Categories/Family for anti-XK antibody

Antibodies; Transport Proteins

References

1. Miranda, M., et al. Mov. Disord. 22(9):1358-1361(2007). 2. Claperon, A., et al. Brain Res. 1147, 12-24 (2007). 3. Walker, R.H., et al. Transfusion 47(2):299-305(2007). 4. Olsen, J.V., et al. Cell 127(3):635-648(2006). 5. Jung, H.H., et al. Transfusion 43(7):928-938(2003).

NCBI and Uniprot Product Information

• NCBI GI #: 10835267
• NCBI GeneID: 7504
• NCBI Accession #: NP_066569.1
• NCBI GenBank Nucleotide #: NM_021083.2
• UniProt Accession #: P51811; Q4TTN6; Q8IUK6; Q9UC77
• Molecular Weight: 50,902 Da
• NCBI Official Full Name: membrane transport protein XK
• NCBI Official Synonym Full Names: X-linked Kx blood group
• NCBI Official Symbol: XK
• NCBI Official Synonym Symbols: KX; NA; NAC; X1k; XKR1; MCLDS
• NCBI Protein Information: membrane transport protein XK; Kx antigen; neurocanthocytosis; neuroacanthocytosis; XK-related protein 1; kell complex 37 kDa component; Kell blood group precursor (McLeod phenotype); XK, Kell blood group complex subunit (McLeod syndrome)
• UniProt Protein Name: Membrane transport protein XK
• Protein Family: XK-related protein
• UniProt Gene Name: XK
• UniProt Synonym Gene Names: XKR1; XRG1
• UniProt Entry Name: XK_HUMAN

NCBI Description

This locus controls the synthesis of the Kell blood group 'precursor substance' (Kx). Mutations in this gene have been associated with McLeod syndrome, an X-linked, recessive disorder characterized by abnormalities in the neuromuscular and hematopoietic systems. The encoded protein has structural characteristics of prokaryotic and eukaryotic membrane transport proteins. [provided by RefSeq, Jul 2008]

Uniprot Description

XK: May be involved in sodium-dependent transport of neutral amino acids or oligopeptides. Defects in XK are the cause of McLeod syndrome (MLS). It is an X-linked multisystem disorder characterized by late onset abnormalities in the neuromuscular and hematopoietic systems. Belongs to the XK family.

Protein type: Cell surface; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: Xp21.1

Cellular Component: integral to membrane

Molecular Function: protein binding; transporter activity

Biological Process: myelination; cellular calcium ion homeostasis; transport; amino acid transport; regulation of axon diameter; skeletal muscle fiber development; regulation of cell size

Disease: Mcleod Syndrome