Goat WIPF1 Polyclonal Antibody | anti-WIPF1 antibody

WIPF1 (WAS/WASL interacting protein family, Member 1, MGC111041, PRPL-2, PRPL-2 protein, WAS/WASL interacting protein family member 1, WASP-interacting protein, WASPIP, WIP, Wiskott-Aldrich syndrome protein interacting protein, Wiskott-Aldrich syndrome pr

Cat. Num. AAA623297

• Gene Names: WIPF1; WIP; PRPL-2; WASPIP; MGC111041
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by affinity chromatography.
• Synonyms: WIPF1; Polyclonal Antibody; WIPF1 (WAS/WASL interacting protein family; Member 1; MGC111041; PRPL-2; PRPL-2 protein; WAS/WASL interacting protein family member 1; WASP-interacting protein; WASPIP; WIP; Wiskott-Aldrich syndrome protein interacting protein; Wiskott-Aldrich syndrome pr; Anti -WIPF1 (WAS/WASL interacting protein family; anti-WIPF1 antibody

• Host: Goat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human WIPF1 at ~55kD. Species sequence homology: mouse, rat, canine.
• Purity/Purification: Affinity Purified; Purified by affinity chromatography.
• Form/Format: Supplied as a liquid in Tris, pH 7.3, 0.5% BSA, 0.02% sodium azide.

• Applicable Applications for anti-WIPF1 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: ELISA: 1:64,000; Western Blot: 0.03-0.1ug/ml; Optimal dilutions to be determined by the researcher
• Immunogen: Synthetic peptide, C-KLARNESRSGSNRRE, from the C-Terminus of human WIPF1.
• Positive Control: Human Lymph Node, Spleen and Tonsil lysates
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 monthsat -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-WIPF1 antibody

This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene.

Product Categories/Family for anti-WIPF1 antibody

Antibodies; Abs to Disease Markers

NCBI and Uniprot Product Information

• NCBI GI #: 38373695
• NCBI GeneID: 7456
• NCBI Accession #: NP_003378.3
• NCBI GenBank Nucleotide #: NM_003387.4
• UniProt Accession #: O43516; Q15220; Q53TA9; Q6MZU9; Q9BU37; Q9UNP1; B8ZZM1; D3DPE4; Q2YDC4
• Molecular Weight: 51,258 Da
• NCBI Official Full Name: WAS/WASL-interacting protein family member 1
• NCBI Official Synonym Full Names: WAS/WASL interacting protein family, member 1
• NCBI Official Symbol: WIPF1
• NCBI Official Synonym Symbols: WIP; PRPL-2; WASPIP; MGC111041
• NCBI Protein Information: WAS/WASL-interacting protein family member 1; protein PRPL-2; OTTHUMP00000163172; OTTHUMP00000163178; OTTHUMP00000205182; OTTHUMP00000205183; OTTHUMP00000205184; WASP-interacting protein; Wiskott-Aldrich syndrome protein interacting protein; wiskott-Aldrich syndrome protein-interacting protein
• UniProt Protein Name: WAS/WASL-interacting protein family member 1
• Protein Family: WAS/WASL-interacting protein family
• UniProt Gene Name: WIPF1
• UniProt Synonym Gene Names: WASPIP; WIP
• UniProt Entry Name: WIPF1_HUMAN

NCBI Description

This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq]

Uniprot Description

WIPF1: a cytoskeleton-associated protein that interacts with the Wiskott-Aldrich syndrome protein (WASP) in resting cells. Plays an important role in the organization of the actin cytoskeleton. Phosphorylation by PKC-theta following T cell receptor signaling disengages it from WASP, releasing WASP from WIP inhibition. Binds to a region of WASP that is frequently mutated in Wiskott-Aldrich syndrome.

Protein type: Motility/polarity/chemotaxis; Actin-binding

Chromosomal Location of Human Ortholog: 2q31.1

Cellular Component: ruffle; cytoplasmic membrane-bound vesicle; actin filament; cytosol; actin cytoskeleton

Molecular Function: protein binding; actin binding; profilin binding

Biological Process: actin filament-based movement; actin polymerization and/or depolymerization; innate immune response; protein complex assembly; response to other organism

Disease: Wiskott-aldrich Syndrome 2