Rabbit WIG1 Polyclonal Antibody | anti-WIG1 antibody

WIG1 Polyclonal Antibody

Cat. Num. AAA3006349

• Gene Names: ZMAT3; WIG1; WIG-1; PAG608
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: WIG1; Polyclonal Antibody; WIG1 Polyclonal Antibody; Zinc finger matrin-type protein 3; Zinc finger protein WIG-1; p53-activated gene 608 protein; ZMAT3; PAG608; anti-WIG1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: WIG1 polyclonal antibody detects endogenous levels of WIG1 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 289

• Applicable Applications for anti-WIG1 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to residues in Human WIG1.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of WIG1 polyclonal antibody at 1:500 dilutionLane1:HEK293T whole cell lysateLane2:Raw264. 7 whole cell lysateLane3:H9C2 whole cell lysate)

Related Product Information for anti-WIG1 antibody

p53 is a DNA-binding protein that is involved in a variety of processes, including tumor suppression and apoptosis, DNA replication and repair, and cell cycle regulation. Normal cells and tissues express a low level of p53 under most circumstances, but p53 expression is induced by DNA damage and cellular stress. Wig-1 (wild type p53-induced gene 1) is a zinc finger protein that contains a putative nuclear localization signal (NLS) and is induced by p53. Wig-1 expression is increased by whole body gamma irradiation in these tissues as well as in spleen and lung.

NCBI and Uniprot Product Information

• NCBI GI #: 11968019
• NCBI GeneID: 64393
• NCBI Accession #: NP_071915.1
• NCBI GenBank Nucleotide #: NP_071915.1
• UniProt Accession #: Q9HA38
• Molecular Weight: ~ 32kDa
• NCBI Official Full Name: zinc finger matrin-type protein 3 isoform 1
• NCBI Official Synonym Full Names: zinc finger matrin-type 3
• NCBI Official Symbol: ZMAT3
• NCBI Official Synonym Symbols: WIG1; WIG-1; PAG608
• NCBI Protein Information: zinc finger matrin-type protein 3
• UniProt Protein Name: Zinc finger matrin-type protein 3
• UniProt Gene Name: ZMAT3
• UniProt Entry Name: ZMAT3_HUMAN

NCBI Description

This gene encodes a protein containing three zinc finger domains and a nuclear localization signal. The mRNA and the protein of this gene are upregulated by wildtype p53 and overexpression of this gene inhibits tumor cell growth, suggesting that this gene may have a role in the p53-dependent growth regulatory pathway. Alternative splicing of this gene results in two transcript variants encoding two isoforms differing in only one amino acid. [provided by RefSeq, Jul 2008]

Uniprot Description

ZMAT3: Acts as a bona fide target gene of p53/TP53. May play a role in the TP53-dependent growth regulatory pathway. May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and nucleolus. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleolus

Chromosomal Location of Human Ortholog: 3q26.32

Cellular Component: nucleolus

Molecular Function: protein binding; zinc ion binding

Biological Process: protein transport; positive regulation of apoptosis; apoptosis; regulation of growth; response to DNA damage stimulus