WD repeat domain phosphoinositide-interacting protein 4 (WDR45) Recombinant Protein | WDR45 recombinant protein

Recombinant Human WD repeat domain phosphoinositide-interacting protein 4 (WDR45)

Cat. Num. AAA7096921

• Gene Names: WDR45; JM5; NBIA4; NBIA5; WDRX1; WIPI4; WIPI-4
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: WD repeat domain phosphoinositide-interacting protein 4 (WDR45); Recombinant Human WD repeat domain phosphoinositide-interacting protein 4 (WDR45); WD repeat-containing protein 45; WDR45 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-360aa; Full Length
• Sequence: MTQQPLRGVTSLRFNQDQSCFCCAMETGVRIYNVEPLMEKGHLDHEQVGSMGLVEMLHRSNLLALVGGGSSPKFSEISVLIWDDAREGKDSKEKLVLEFTFTKPVLSVRMRHDKIVIVLKNRIYVYSFPDNPRKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGHKCGSLQLVDLASTKPGTSSAPFTINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPATLYCINFSHDSSFLCASSDKGTVHIFALKDTRLNRRSALARVGKVGPMIGQYVDSQWSLASFTVPAESACICAFGRNTSKNVNSVIAICVDGTFHKYVFTPDGNCNREAFDVYLDICDDDDF
• Sequence Length: 361

• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

SDS-PAGE

Related Product Information for WDR45 recombinant protein

Plays an important role in the autophagy pathway, which is the major intracellular degradation system by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation.

Product Categories/Family for WDR45 recombinant protein

Cell Biology

References

"WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy." Proikas-Cezanne T., Waddell S., Gaugel A., Frickey T., Lupas A., Nordheim A. Oncogene 23:9314-9325(2004)

NCBI and Uniprot Product Information

• NCBI GI #: 71483646
• NCBI GeneID: 11152
• NCBI Accession #: NP_001025067.1
• NCBI GenBank Nucleotide #: NM_001029896.1
• UniProt Accession #: Q9Y484; Q5MNZ5; Q6IBS7; Q6NT94; Q96H03; A6NGH5; B7WPI2
• Molecular Weight: 66.9 kDa
• NCBI Official Full Name: WD repeat domain phosphoinositide-interacting protein 4 isoform 2
• NCBI Official Synonym Full Names: WD repeat domain 45
• NCBI Official Symbol: WDR45
• NCBI Official Synonym Symbols: JM5; NBIA4; NBIA5; WDRX1; WIPI4; WIPI-4
• NCBI Protein Information: WD repeat domain phosphoinositide-interacting protein 4
• UniProt Protein Name: WD repeat domain phosphoinositide-interacting protein 4
• Protein Family: WD repeat domain phosphoinositide-interacting protein
• UniProt Gene Name: WDR45
• UniProt Synonym Gene Names: WDRX1; WDRXI4; WIPI4; WIPI-4

NCBI Description

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene has a pseudogene at chromosome 4q31.3. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity and full-length nature of some variants have not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

Plays an important role in the autophagy pathway, which is the major intracellular degradation system by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation.