Rabbit anti-Human WDR34 Polyclonal Antibody | anti-WDR34 antibody

WDR34 Antibody

Cat. Num. AAA7000084

• Gene Names: WDR34; DIC5; FAP133; SRTD11; bA216B9.3
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >95%,Protein G purified
• Synonyms: WDR34; Polyclonal Antibody; WDR34 Antibody; WD repeat-containing protein 34; anti-WDR34 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%,Protein G purified
• Form/Format: Liquid
• Sequence Length: 536

• Applicable Applications for anti-WDR34 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Recombinant human WD repeat-containing protein 34 protein
• Conjugation: Non-conjugated
• Storage Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Preparation and Storage: Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.

Western Blot (WB)

(Western blotAll lanes: WDR34 antibody at 1.5ug/mlLane 1: PC-3 whole cell lysateLane 2: MDA-MB-231 whole cell lysateSecondaryGoat polyclonal to Rabbit IgG at 1/10000 dilutionPredicted band size: 58 kDaObserved band size: 58 kDa)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human gastric cancer using MBS7000084 at dilution of 1:100)

Related Product Information for anti-WDR34 antibody

Critical for ciliary functions, essential to normal development and survival, most probably as a previously unrecognized component of the mammalian dynein-motor-based intraflagellar transport (IFT) machinery. Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation.

NCBI and Uniprot Product Information

• NCBI GI #: 66267730
• NCBI GeneID: 89891
• NCBI Accession #: NP_443076.2
• NCBI GenBank Nucleotide #: NM_052844.3
• UniProt Accession #: Q96EX3; Q5VXV4; Q9BV46
• Molecular Weight: 57,801 Da
• NCBI Official Full Name: WD repeat-containing protein 34
• NCBI Official Synonym Full Names: WD repeat domain 34
• NCBI Official Symbol: WDR34
• NCBI Official Synonym Symbols: DIC5; FAP133; SRTD11; bA216B9.3
• NCBI Protein Information: WD repeat-containing protein 34
• UniProt Protein Name: WD repeat-containing protein 34
• Protein Family: WD repeat-containing protein
• UniProt Gene Name: WDR34
• UniProt Entry Name: WDR34_HUMAN

NCBI Description

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Defects in this gene are a cause of short-rib thoracic dysplasia 11 with or without polydactyly. [provided by RefSeq, Mar 2014]

Uniprot Description

WDR34: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa- B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation.

Chromosomal Location of Human Ortholog: 9q34.11

Cellular Component: axoneme; centriole; cytoplasm; cytoplasmic dynein complex

Molecular Function: protein binding

Biological Process: organelle organization and biogenesis

Disease: Short-rib Thoracic Dysplasia 11 With Or Without Polydactyly