Rabbit WAVE3 Polyclonal Antibody | anti-WASF3 antibody

WAVE3 (Scar3)

Cat. Num. AAA610095

• Gene Names: WASF3; SCAR3; WAVE3; Brush-1; KIAA0900
• Reactivity: Human, Monkey, Mouse, Rat
• Applications: ELISA, Western Blot, Immunoprecipitation
• Purity: Supernatant; Supernatant.
• Synonyms: WAVE3; Polyclonal Antibody; WAVE3 (Scar3); Anti -WAVE3 (Scar3); anti-WASF3 antibody

• Host: Rabbit
• Reactivity: Human, Monkey, Mouse, Rat
• Clonality: Polyclonal
• Specificity: Detects endogenous levels of total WAVE-3 protein. The antibody does not cross-react with WAVE-1 or WAVE-2.
• Purity/Purification: Supernatant; Supernatant.
• Form/Format: Supplied as a liquid in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100ug/ml BSA and 50% glycerol.

• Applicable Applications for anti-WASF3 antibody: ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP)
• Application Notes: Suitable for use in ELISA, Western Blot and Immunoprecipitation.; Dilution: Western Blot: 1:1000; Immunoprecipitation: 1:50
• Immunogen: Synthetic peptide (KLH-coupled) corresponding to the central sequence of human WAVE-3.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Western Blot (WB)

(Western blot analysis of extracts from various cell types using MBS610095.)

Western Blot (WB)

(Immunoprecipitation of WAVE-3 from SH-SY5Y extracts using MBS610095(lane 2). Lane 1 is 5% input. Western blot detection was performed using the same antibody.)

Product Categories/Family for anti-WASF3 antibody

Antibodies; Abs to Disease Markers

NCBI and Uniprot Product Information

• NCBI GI #: 13699803
• NCBI GeneID: 10810
• NCBI Accession #: NP_006637.2
• NCBI GenBank Nucleotide #: NM_006646.5
• UniProt Accession #: Q5T8P4; Q86VQ2; Q9UPY6
• Molecular Weight: 55,293 Da
• NCBI Official Full Name: wiskott-Aldrich syndrome protein family member 3
• NCBI Official Synonym Full Names: WAS protein family, member 3
• NCBI Official Symbol: WASF3
• NCBI Official Synonym Symbols: SCAR3; WAVE3; Brush-1; KIAA0900
• NCBI Protein Information: wiskott-Aldrich syndrome protein family member 3; protein WAVE-3; OTTHUMP00000018160; WASP family protein member 3; WASP family Verprolin-homologous protein 3; verprolin homology domain-containing protein 3
• UniProt Protein Name: WAS protein family, member 3
• Protein Family: Wiskott-Aldrich syndrome protein family
• UniProt Gene Name: WASF3
• UniProt Entry Name: Q5T8P4_HUMAN

NCBI Description

This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. [provided by RefSeq]

Uniprot Description

WASF3: Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. Binds actin and the Arp2/3 complex. Expressed in ovary and brain. Belongs to the SCAR/WAVE family.

Protein type: Motility/polarity/chemotaxis; Actin-binding

Chromosomal Location of Human Ortholog: 13q12

Cellular Component: cytoskeleton; lamellipodium; cytoplasm

Molecular Function: actin binding

Biological Process: lamellipodium biogenesis; positive regulation of myelination; regulation of cell shape; actin filament polymerization; cytoskeleton organization and biogenesis; protein complex assembly; oligodendrocyte development