Western Blot (WB)
(Anti- VWF Picoband antibody, MBS178323, Western blottingAll lanes: Anti VWF (MBS178323) at 0.5ug/mlWB: Recombinant Mouse VWF Protein 0.5ngPredicted bind size: 37KDObserved bind size: 37KD)
anti-Mouse, Rat VWF Polyclonal Antibody | anti-VWF antibody
Anti-VWF Antibody
Immunohistochemistry (IHC) Paraffin Concentration: 0.5-1ug/ml
Western Blot (WB)
(Anti- VWF Picoband antibody, MBS178323, Western blottingAll lanes: Anti VWF (MBS178323) at 0.5ug/mlWB: Recombinant Mouse VWF Protein 0.5ngPredicted bind size: 37KDObserved bind size: 37KD)
Western Blot (WB)
(Anti- VWF Picoband antibody, MBS178323, Western blottingAll lanes: Anti VWF (MBS178323) at 0.5ug/mlWB: Recombinant Mouse VWF Protein 0.5ngPredicted bind size: 37KDObserved bind size: 37KD)
Western Blot (WB)
(Anti- VWF Picoband antibody, MBS178323, Western blottingAll lanes: Anti VWF (MBS178323) at 0.5ug/mlWB: Mouse Lung Tissue Lysate at 50ugPredicted bind size: 309KDObserved bind size: 309KD )
Western Blot (WB)
(Anti- VWF Picoband antibody, MBS178323, Western blottingAll lanes: Anti VWF (MBS178323) at 0.5ug/mlWB: Mouse Lung Tissue Lysate at 50ugPredicted bind size: 309KDObserved bind size: 309KD )
Immunohistochemistry (IHC)
(Anti- VWF Picoband antibody, MBS178323, IHC(P)IHC(P): Mouse Liver Tissue )
Immunohistochemistry (IHC)
(Anti- VWF Picoband antibody, MBS178323, IHC(P)IHC(P): Mouse Liver Tissue )
Background: Von Willebrand factor (VWF) is a blood glycoprotein involved in hemostasis. It is mapped to 12p13.31. The VWF gene encodes von Willebrand factor (VWF), a large multimeric glycoprotein that plays a central role in the blood coagulation system, serving both as a major mediator of platelet-vessel wall interaction and platelet adhesion, and as a carrier for coagulation factor VIII. VWF released from endothelial cell Weibel-Palade bodies bound particularly avidly to the extracellular matrix. VWF deficiency or dysfunction (von Willebrand disease) leads to a bleeding tendency, which is most apparent in tissues having high blood flow shear in narrow vessels.
NCBI and Uniprot Product Information
Uniprot Description
VWF: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. Defects in VWF are the cause of von Willebrand disease type 1 (VWD1). A common hemorrhagic disorder due to defects in von Willebrand factor protein and resulting in impaired platelet aggregation. Von Willebrand disease type 1 is characterized by partial quantitative deficiency of circulating von Willebrand factor, that is otherwise structurally and functionally normal. Clinical manifestations are mucocutaneous bleeding, such as epistaxis and menorrhagia, and prolonged bleeding after surgery or trauma. Defects in VWF are the cause of von Willebrand disease type 2 (VWD2). A hemorrhagic disorder due to defects in von Willebrand factor protein and resulting in impaired platelet aggregation. Von Willebrand disease type 2 is characterized by qualitative deficiency and functional anomalies of von Willebrand factor. It is divided in different subtypes including 2A, 2B, 2M and 2N (Normandy variant). The mutant VWF protein in types 2A, 2B and 2M are defective in their platelet- dependent function, whereas the mutant protein in type 2N is defective in its ability to bind factor VIII. Clinical manifestations are mucocutaneous bleeding, such as epistaxis and menorrhagia, and prolonged bleeding after surgery or trauma. Defects in VWF are the cause of von Willebrand disease type 3 (VWD3). A severe hemorrhagic disorder due to a total or near total absence of von Willebrand factor in the plasma and cellular compartments, also leading to a profound deficiency of plasmatic factor VIII. Bleeding usually starts in infancy and can include epistaxis, recurrent mucocutaneous bleeding, excessive bleeding after minor trauma, and hemarthroses.
Protein type: Motility/polarity/chemotaxis; Cell adhesion; Secreted, signal peptide; Secreted; Extracellular matrix
Cellular Component: endoplasmic reticulum; external side of plasma membrane; extracellular matrix; extracellular region; proteinaceous extracellular matrix
Molecular Function: chaperone binding; collagen binding; glycoprotein binding; identical protein binding; immunoglobulin binding; integrin binding; protease binding; protein binding; protein homodimerization activity; protein N-terminus binding
Biological Process: blood coagulation; cell adhesion; cell-substrate adhesion; hemostasis; liver development; placenta development; platelet activation; protein homooligomerization
Research Articles on VWF
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Product Notes
The VWF vwf (Catalog #AAA178323) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-VWF Antibody reacts with Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's VWF can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. Western Blot Concentration: 0.1-0.5ug/ml Immunohistochemistry (IHC) Paraffin Concentration: 0.5-1ug/ml. Researchers should empirically determine the suitability of the VWF vwf for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "VWF, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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