Rabbit VRL1 Polyclonal Antibody | anti-TRPV2 antibody

VRL1 Antibody

Cat. Num. AAA9629204

• Gene Names: TRPV2; VRL; VRL1; VRL-1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: VRL1; Polyclonal Antibody; VRL1 Antibody; MGC12549; Osm 9 like TRP channel 2; Osm-9-like TRP channel 2; OTRPC2; Sac2b; Stretch activated channel 2B; Transient receptor potential cation channel subfamily V member 2; TRPV2; TRPV2_HUMAN; Vanilloid receptor like protein 1; Vanilloid receptor-like protein 1; VRL 1; VRL; VRL-1; anti-TRPV2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: VRL1 Antibody detects endogenous levels of total VRL1.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-TRPV2 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from Human MYOCD.
• Conjugation: Unconjugated
• Similarity: Belongs to the transient receptor (TC 1. A. 4) family. TrpV subfamily. TRPV2 sub-subfamily.
• Post Translational Modifications: N-glycosylated.Phosphorylated by PKA.
• Subunit Structure: Homotetramer (Probable). Interacts with a cAMP-dependent protein kinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ACBD3. Interacts with SLC50A1; the interaction probably occurs intracellularly and depends on TRPV2 N-glycosylation (By similarity).
• Function: Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH.
• Note: Translocates from the cytoplasm to the plasma membrane upon ligand stimulation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-TRPV2 antibody

Cell membrane; Multi-pass membrane protein; Cytoplasm; Melanosome; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 20127551
• NCBI GeneID: 51393
• NCBI Accession #: NP_057197.2
• NCBI GenBank Nucleotide #: NM_016113.4
• UniProt Accession #: Q9Y5S1; Q9Y670; A6NML2; A8K0Z0
• Molecular Weight: 85,981 Da
• NCBI Official Full Name: transient receptor potential cation channel subfamily V member 2
• NCBI Official Synonym Full Names: transient receptor potential cation channel subfamily V member 2
• NCBI Official Symbol: TRPV2
• NCBI Official Synonym Symbols: VRL; VRL1; VRL-1
• NCBI Protein Information: transient receptor potential cation channel subfamily V member 2
• UniProt Protein Name: Transient receptor potential cation channel subfamily V member 2
• Protein Family: Transient receptor potential cation channel subfamily
• UniProt Gene Name: TRPV2
• UniProt Synonym Gene Names: VRL; TrpV2; OTRPC2; VRL-1

NCBI Description

This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat. [provided by RefSeq, Jul 2008]

Uniprot Description

Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH.