Rabbit VPS72 Polyclonal Antibody | anti-VPS72 antibody

VPS72 Rabbit Polyclonal

Cat. Num. AAA7605683

• Gene Names: VPS72; YL1; CFL1; Swc2; YL-1; TCFL1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: VPS72; Polyclonal Antibody; VPS72 Rabbit Polyclonal; anti-VPS72 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 375

• Applicable Applications for anti-VPS72 antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: Vacuolar protein sorting 72 homolog (S. cerevisiae)
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Western Blot (WB)

(mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with MBS7605683 (VPS72 antibody) at dilution of 1:800)

NCBI and Uniprot Product Information

• NCBI GI #: 402793870
• NCBI GeneID: 6944
• NCBI Accession #: NP_001258016.1
• NCBI GenBank Nucleotide #: NM_001271087.1
• Molecular Weight: 41,848 Da
• NCBI Official Full Name: vacuolar protein sorting-associated protein 72 homolog isoform 1
• NCBI Official Synonym Full Names: vacuolar protein sorting 72 homolog
• NCBI Official Symbol: VPS72
• NCBI Official Synonym Symbols: YL1; CFL1; Swc2; YL-1; TCFL1
• NCBI Protein Information: vacuolar protein sorting-associated protein 72 homolog
• UniProt Protein Name: Vacuolar protein sorting-associated protein 72 homolog
• Protein Family: Vacuolar protein sorting-associated protein
• UniProt Gene Name: VPS72
• UniProt Synonym Gene Names: TCFL1; YL1
• UniProt Entry Name: VPS72_HUMAN

NCBI Description

The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell activity. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

Uniprot Description

VPS72: Could be a DNA-binding transcriptional regulator. May be involved in chromatin modification and remodeling. Belongs to the VPS72/YL1 family.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: nucleoplasm; nucleus; protein complex

Molecular Function: DNA binding; protein binding

Biological Process: histone exchange; negative regulation of transcription from RNA polymerase II promoter; somatic stem cell maintenance; transcription, DNA-dependent