Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using VPS4A Polyclonal Antibody at dilution 1:40)
Rabbit VPS4A Polyclonal Antibody | anti-VPS4A antibody
VPS4A Polyclonal Antibody
IHC: 1:30-150
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using VPS4A Polyclonal Antibody at dilution 1:40)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using VPS4A Polyclonal Antibody at dilution 1:40)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human prostate cancer tissue using VPS4A Polyclonal Antibody at dilution 1:40)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human prostate cancer tissue using VPS4A Polyclonal Antibody at dilution 1:40)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really an yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18. [provided by RefSeq, Jul 2008]
Uniprot Description
VPS4A: Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Involved in cytokinesis. Belongs to the AAA ATPase family.
Protein type: EC 3.6.4.6; Vesicle
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component: centrosome; cytoplasm; cytosol; early endosome; endosome; late endosome; lysosome; midbody; nucleus; perinuclear region of cytoplasm; plasma membrane; spindle pole; vacuolar membrane
Molecular Function: ATP binding; ATPase activity; microtubule-severing ATPase activity; protein binding; protein C-terminus binding; protein domain specific binding
Biological Process: abscission; cell division; cell separation during cytokinesis; cytoplasmic microtubule organization and biogenesis; endosomal vesicle fusion; endosome transport; intracellular cholesterol transport; membrane budding; mitotic metaphase plate congression; negative regulation of cytokinesis; nuclear organization and biogenesis; regulation of protein localization; release of virus from host; ubiquitin-dependent protein catabolic process via the multivesicular body pathway; vacuole organization and biogenesis; vesicle-mediated transport; viral infectious cycle
Research Articles on VPS4A
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Product Notes
The VPS4A vps4a (Catalog #AAA2542961) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The VPS4A Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's VPS4A can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). ELISA: 1:2000-10000 IHC: 1:30-150. Researchers should empirically determine the suitability of the VPS4A vps4a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "VPS4A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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