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Immunohistochemistry (IHC) (Anti-VPS37C antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.)

Goat VPS37C Polyclonal Antibody | anti-VPS37C antibody

Goat Polyclonal to Human VPS37C

Reactivity
Gibbon, Gorilla, Human, Orangutan
Predicted Reactivity: Monkey, Bat, Rabbit (at least 90% immunogen sequence identity)
Applications
Immunohistochemistry, Western Blot, ELISA
Purity
Immunoaffinity Purified
Synonyms
VPS37C; Polyclonal Antibody; Goat Polyclonal to Human VPS37C; Anti-VPS37C Antibody (Internal) IHC-plus; HVps37C; PML39; Vacuolar protein sorting 37C; ESCRT-I complex subunit VPS37C; Human VPS37C; anti-VPS37C antibody
Ordering
For Research Use Only!
Host
Goat
Reactivity
Gibbon, Gorilla, Human, Orangutan
Predicted Reactivity: Monkey, Bat, Rabbit (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Specificity
Human VPS37C.
Purity/Purification
Immunoaffinity Purified
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Concentration
0.5 mg/ml (varies by lot)
Sequence Length
355
Applicable Applications for anti-VPS37C antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes
ELISA (1:32000), IHC-P (3.75 ug/ml), WB (1:32000, 0.1 ug/ml)
Target Species
Human
Immunogen Description
Synthetic peptide C-ETLKDKTLQELEELQ from an internal region of human VPS37C (NP_060436.4). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Marmoset (100%); Monkey, Bat, Rabbit (93%); Mouse, Rat, Hamster, Bovine, Dog, Horse (87%).
Immunogen Type
Synthetic peptide
Immunogen
VPS37C antibody was raised against synthetic peptide C-ETLKDKTLQELEELQ from an internal region of human VPS37C (NP_060436.4). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Marmoset (100%); Monkey, Bat, Rabbit (93%); Mouse, Rat, Hamster, Bovine, Dog, Horse (87%); Elephant (80%).
Antigen Modification
Internal
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC)

(Anti-VPS37C antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.)

Immunohistochemistry (IHC) (Anti-VPS37C antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.)

Immunohistochemistry (IHC)

(Anti-VPS37C antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.)

Immunohistochemistry (IHC) (Anti-VPS37C antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.)

Western Blot (WB)

(Antibody (0.03g/ml) staining of human duodenum lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)

Western Blot (WB) (Antibody (0.03g/ml) staining of human duodenum lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
Related Product Information for anti-VPS37C antibody
VPS37C is a subunit of ESCRT-I (endosomal sorting complex required for transport I), a complex in the class E vacuolar protein sorting (VPS) pathway required for sorting ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
38,659 Da
NCBI Official Full Name
vacuolar protein sorting-associated protein 37C
NCBI Official Synonym Full Names
vacuolar protein sorting 37 homolog C (S. cerevisiae)
NCBI Official Symbol
VPS37C
NCBI Protein Information
vacuolar protein sorting-associated protein 37C; hVps37C; vacuolar protein sorting 37C; ESCRT-I complex subunit VPS37C
UniProt Protein Name
Vacuolar protein sorting-associated protein 37C
UniProt Gene Name
VPS37C
UniProt Synonym Gene Names
PML39; hVps37C
UniProt Entry Name
VP37C_HUMAN

NCBI Description

VPS37C is a subunit of ESCRT-I (endosomal sorting complex required for transport I), a complex in the class E vacuolar protein sorting (VPS) pathway required for sorting ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies (Eastman et al., 2005 [PubMed 15509564]).[supplied by OMIM, Mar 2008]

Uniprot Description

VPS37C: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. Belongs to the VPS37 family.

Chromosomal Location of Human Ortholog: 11q12.2

Cellular Component: late endosome membrane; endosome membrane

Molecular Function: protein binding; calcium-dependent protein binding

Biological Process: protein transport; viral reproduction; viral protein processing; viral infectious cycle; virus assembly; endosome transport

Research Articles on VPS37C

Similar Products

Product Notes

The VPS37C vps37c (Catalog #AAA242805) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat Polyclonal to Human VPS37C reacts with Gibbon, Gorilla, Human, Orangutan Predicted Reactivity: Monkey, Bat, Rabbit (at least 90% immunogen sequence identity) and may cross-react with other species as described in the data sheet. AAA Biotech's VPS37C can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA). ELISA (1:32000), IHC-P (3.75 ug/ml), WB (1:32000, 0.1 ug/ml). Researchers should empirically determine the suitability of the VPS37C vps37c for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "VPS37C, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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