Rabbit anti-Human VPS26B Polyclonal Antibody | anti-VPS26B antibody

VPS26B Antibody

Cat. Num. AAA1498295

• Gene Names: VPS26B; Pep8b
• Reactivity: Human
• Applications: ELISA
• Purity: >95%, Protein G Purified
• Synonyms: VPS26B; Polyclonal Antibody; VPS26B Antibody; Vacuolar protein sorting-associated protein 26B; Vesicle protein sorting 26B; anti-VPS26B antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G Purified
• Sequence Length: 336

• Applicable Applications for anti-VPS26B antibody: ELISA (EIA)
• Storage Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Conjugate: Non-conjugated
• Immunogen: Recombinant human Vacuolar protein sorting-associated protein 26B protein
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-109457 / sc-109458
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Western Blot (WB)

(Western BlotPositive WB detected in: Mouse brain tissueAll lanes: VPS26B antibody at 3.4ug/mlSecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 40 KDaObserved band size: 40 KDa)

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of human colon cancer using MBS1498295 at dilution of 1:100)

Immunohistochemistry (IHC)

(Immunofluorescent analysis of PC3 cells using MBS1498295 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))

Related Product Information for anti-VPS26B antibody

Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. May be involved in retrograde transport of SORT1 but not of IGF2R. Acts redundantly with VSP26A in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1 (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 16418381
• NCBI GeneID: 112936
• NCBI Accession #: NP_443107.1
• NCBI GenBank Nucleotide #: NM_052875.4
• UniProt Accession #: Q4G0F5; Q96A55
• Molecular Weight: 39,155 Da
• NCBI Official Full Name: vacuolar protein sorting-associated protein 26B
• NCBI Official Synonym Full Names: VPS26 retromer complex component B
• NCBI Official Symbol: VPS26B
• NCBI Official Synonym Symbols: Pep8b
• NCBI Protein Information: vacuolar protein sorting-associated protein 26B
• UniProt Protein Name: Vacuolar protein sorting-associated protein 26B
• Protein Family: Vacuolar protein sorting-associated protein
• UniProt Gene Name: VPS26B
• UniProt Entry Name: VP26B_HUMAN

Uniprot Description

VPS26B: Probable component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Belongs to the VPS26 family.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 11q25

Cellular Component: cytosol; early endosome; late endosome; retromer complex

Molecular Function: protein transporter activity

Biological Process: protein transport; retrograde transport, endosome to Golgi