Chicken anti-Human Von Hippel-Lindau Related Protein Polyclonal Antibody | anti-VHL antibody

Von Hippel-Lindau Related Protein (vHL)

Cat. Num. AAA618438

• Reactivity: Human
• Applications: ELISA
• Purity: Highly Purified; 98% No contaminants detected. Single band by SDS-PAGE, IEP, and/or RID.
• Synonyms: Von Hippel-Lindau Related Protein; Polyclonal Antibody; Von Hippel-Lindau Related Protein (vHL); Anti -Von Hippel-Lindau Related Protein (vHL); anti-VHL antibody

• Host: Chicken
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgY
• Specificity: Recognizes Von-Hippel-Landau Related Protein.
• Purity/Purification: Highly Purified; 98% No contaminants detected. Single band by SDS-PAGE, IEP, and/or RID.
• Form/Format: Tris buffer, pH 7.4, 0.1% sodium azide

• Applicable Applications for anti-VHL antibody: ELISA (EL/EIA)
• Application Notes: Suitable for use in ELISA.
• Immunogen: Von-Hippel-Landau Related Protein.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-VHL antibody

Molecular genetic studies suggest that VHL is a tumor-suppressor gene. Alterations in the von Hippel-Lindau (VHL) gene are correlated with a diverse group of neoplasms including hemangioblastoma, clear cell renal carcinoma (RCC), and pheochromocytoma. Two transcriptional elongation factors, Elongin B and C, are shown to bind in vitro and in vivo to a short, colinear region of the VHL protein (pVHL) that is frequently mutated in human tumors. It is proposed that pVHL functions in vivo as a negative regulator of transcription elongation.

Product Categories/Family for anti-VHL antibody

Antibodies; Abs to Disease Markers

NCBI and Uniprot Product Information

• NCBI GI #: 444722814
• UniProt Accession #: Q5Q9Z2
• Molecular Weight: 24,467 Da
• NCBI Official Full Name: Von Hippel-Lindau disease tumor suppressor
• UniProt Protein Name: Von Hippel-Lindau disease tumor suppressor
• Protein Family: Von Hippel-Lindau disease tumor suppressor
• UniProt Gene Name: VHL
• UniProt Entry Name: VHL_CANFA

Uniprot Description

Function: Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases

By similarity.

Pathway: Protein modification; protein ubiquitination.

Subunit structure: Part of a complex with Elongin BC complex and hydroxylated HIF1A. Interacts with CUL2. Part of multisubunit CBC(VHL) E3 ubiquitin ligase complexes with Elongin BC complex, CUL2 or CUL5 and RBX1. Interacts with HIF1AN. Part of a complex with HIF1A, HIF1AN and HDAC1 or HDAC2 or HDAC3. The C-terminus interacts with VBP1. Interacts with RNF139 and UBP33. Interacts with PHF17

By similarity. Found in a complex composed of LIMD1, VHL, EGLN1/PHD2, TCEB2 AND CUL2. Interacts with LIMD1 (via LIM zinc-binding 2). Interacts with AJUBA (via LIM domains) and WTIP (via LIM domains)

By similarity. Interacts with EPAS1

By similarity.

Subcellular location: Cytoplasm

By similarity. Membrane; Peripheral membrane protein

By similarity. Nucleus

By similarity.

Domain: The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].