Western Blot (WB)
(Western Blot analysis of rat brain lysate probed with MBS621327 at 0.5ug/ml (A), 1ug/ml(B) and 2ug/ml(C).)
Rabbit VISA Polyclonal Antibody | anti-VISA antibody
VISA (Virus-Induced Signaling Adapter, Mitochondrial Antiviral Signaling Protein, MAVS, CARD Adapter Inducing Interferon-beta, Cardif, IPS-1) (AP)
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Immunohistochemistry
Purity
Purified by Immunoaffinity chromatography.
Synonyms
VISA; Polyclonal Antibody; VISA (Virus-Induced Signaling Adapter; Mitochondrial Antiviral Signaling Protein; MAVS; CARD Adapter Inducing Interferon-beta; Cardif; IPS-1) (AP); anti-VISA antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human VISA. Reacts with full length VISA isoform 1. Does not react with isoforms 2, 3, 5 or 6, reactivity with isoform 4 is unknown. Species crossreactivity: mouse, rat
Purity/Purification
Purified by Immunoaffinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2. Labeled with Alkaline Phosphatase.
Applicable Applications for anti-VISA antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
Applications are based on unconjugated antibody.
Immunogen
Synthetic peptide corresponding to a 17aa sequence near the center of human VISA.
Conjugate
AP
Note
Preservative Free
Preparation and Storage
Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Western Blot (WB)
(Western Blot analysis of rat brain lysate probed with MBS621327 at 0.5ug/ml (A), 1ug/ml(B) and 2ug/ml(C).)
Western Blot (WB)
(Western Blot analysis of rat brain lysate probed with MBS621327 at 0.5ug/ml (A), 1ug/ml(B) and 2ug/ml(C).)
Testing Data
(Immunohistological staining of mouse brainMBS621327.)
Testing Data
(Immunohistological staining of mouse brainMBS621327.)
Related Product Information for anti-VISA antibody
VISA is an important protein required for innate immune defence against viruses. VISA acts downstream of DDX58 and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). VISA is believed to activate the same pathways following detection of extracellular dsRNA by TLR3 and it has been hypothosized that VISA may protect cells from apoptosis. VISA is a ubiquitously expressed protein present in a range of cell types including T-cells, monocytes and epithelial cells, highest levels in tissues of the heart, skeletal muscle, liver, placenta and in peripheral blood leukocytes. Multiple isoforms of VISA have been identified.
Product Categories/Family for anti-VISA antibody
References
1. Seth, R.B., et al. (2006). Antiviral innate immunity pathways. Cell Res. 16:141-7 2. Xu LG, et al. (2005). VISA is an adapter protein required for virus-triggered IFN-beta signaling. Mol. Cell 19:727-40. 3. Meylan E, et al. (2005). Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 437(7062):1167-72.
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Product Notes
The VISA (Catalog #AAA6505827) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The VISA (Virus-Induced Signaling Adapter, Mitochondrial Antiviral Signaling Protein, MAVS, CARD Adapter Inducing Interferon-beta, Cardif, IPS-1) (AP) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's VISA can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the VISA for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "VISA, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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