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Immunohistochemistry (IHC) (Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE))

Rabbit VIL1/Villin Polyclonal Antibody | anti-VIL1 antibody

Anti-VIL1/Villin Antibody

Gene Names
VIL1; VIL; D2S1471
Reactivity
Human
Predicted: Mouse, Rat
Applications
Immunohistochemistry, Immunohistochemistry, Western Blot
Purity
Affinity Purified
Synonyms
VIL1/Villin; Polyclonal Antibody; Anti-VIL1/Villin Antibody; Rabbit Polyclonal (IgG) to Human VIL1/Villin; VIL1; D2S1471; Villin; Villin 1; Villin-1; VIL; anti-VIL1 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Predicted: Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
Human VIL1/Villin
Purity/Purification
Affinity Purified
Form/Format
PBS with 0.02% sodium azide, 50% glycerol, pH 7.3
Sequence Length
827
Applicable Applications for anti-VIL1 antibody
Immunohistochemistry (IHC), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
Application Notes
IHC: 1:50-1:100
IHC-P: 1:100
WB: 1:500-1:2000
Immunogen
Recombinant protein of human VIL1
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C.
Avoid freeze-thaw cycles.

Immunohistochemistry (IHC)

(Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE))

Immunohistochemistry (IHC) (Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE))

Immunohistochemistry (WB)

(Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE))

Immunohistochemistry (WB) (Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE))

Western Blot (WB)

(Western blot analysis of extracts of various cell lines.)

Western Blot (WB) (Western blot analysis of extracts of various cell lines.)

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using VIL1 antibody.)

Western Blot (WB) (Western blot analysis of extracts of various cell lines, using VIL1 antibody.)
Related Product Information for anti-VIL1 antibody
Epithelial cell-specific Ca2+-regulated actin-modifying protein thatmodulates the reorganization of microvillar actin filaments. Plays arole in the actin nucleation, actin filament bundle assembly, actinfilament capping and severing. Binds phosphatidylinositol4, 5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA withhigher affinity than PIP2. Binding to LPA increases its phosphorylationby SRC and inhibits all actin-modifying activities.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
46,567 Da
NCBI Official Full Name
villin-1
NCBI Official Synonym Full Names
villin 1
NCBI Official Symbol
VIL1
NCBI Official Synonym Symbols
VIL; D2S1471
NCBI Protein Information
villin-1
UniProt Protein Name
Villin-1
Protein Family
UniProt Gene Name
VIL1
UniProt Synonym Gene Names
VIL

NCBI Description

This gene encodes a member of a family of calcium-regulated actin-binding proteins. This protein represents a dominant part of the brush border cytoskeleton which functions in the capping, severing, and bundling of actin filaments. Two mRNAs of 2.7 kb and 3.5 kb have been observed; they result from utilization of alternate poly-adenylation signals present in the terminal exon. [provided by RefSeq, Jul 2008]

Uniprot Description

Epithelial cell-specific Ca2+-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination.

Research Articles on VIL1

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Product Notes

The VIL1 vil1 (Catalog #AAA2401939) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-VIL1/Villin Antibody reacts with Human Predicted: Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's VIL1/Villin can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Immunohistochemistry (IHC) Paraffin, Western Blot (WB). IHC: 1:50-1:100 IHC-P: 1:100 WB: 1:500-1:2000. Researchers should empirically determine the suitability of the VIL1 vil1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "VIL1/Villin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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