Rabbit anti-Human Vesicular Monoamine Transporter 1 Polyclonal Antibody | anti-SLC18A2 antibody
Vesicular Monoamine Transporter 1 (VMAT1)
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Dilution: Western Blot: 1-10ug/ml using ECL. Detects a major band at ~55 kD in postnuclear supernatants of CHO transfected with VMAT1 and not in wild type cells (2). Some additional bands, both higher and lower MW, were also detected and remain unaffected by the inclusion of protease inhibitors.
ELISA: 0.5-1ug/ml. Control peptide can be used to coat ELISA plates at 1ug/ml.
NCBI and Uniprot Product Information
NCBI Description
The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (summary by Peter et al., 1993 [PubMed 7905859]). See also SLC18A1 (MIM 193002).[supplied by OMIM, Jan 2011]
Uniprot Description
SLC18A2: Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis. Belongs to the major facilitator superfamily. Vesicular transporter family.
Protein type: Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral; Transporter
Chromosomal Location of Human Ortholog: 10q25
Cellular Component: synaptic vesicle; cell soma; membrane; synaptic vesicle membrane; integral to plasma membrane; plasma membrane; terminal button
Molecular Function: serotonin transmembrane transporter activity; enzyme binding; amine transmembrane transporter activity; heat shock protein binding; monoamine transmembrane transporter activity; drug binding
Biological Process: dopamine transport; death; neurotransmitter secretion; amine transport; response to amphetamine; monoamine transport; locomotory behavior; response to herbicide; endocytic recycling; sequestering of neurotransmitter; glucose homeostasis; response to cocaine; post-embryonic development; response to starvation; synaptic transmission; response to zinc ion; insulin secretion; serotonin transport; transmembrane transport; negative regulation of neurotransmitter transport; aging; response to corticosterone stimulus
Research Articles on SLC18A2
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Product Notes
The SLC18A2 slc18a2 (Catalog #AAA626692) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Vesicular Monoamine Transporter 1 (VMAT1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Vesicular Monoamine Transporter 1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in ELISA and Western Blot. Dilution: Western Blot: 1-10ug/ml using ECL. Detects a major band at ~55 kD in postnuclear supernatants of CHO transfected with VMAT1 and not in wild type cells (2). Some additional bands, both higher and lower MW, were also detected and remain unaffected by the inclusion of protease inhibitors. ELISA: 0.5-1ug/ml. Control peptide can be used to coat ELISA plates at 1ug/ml. Researchers should empirically determine the suitability of the SLC18A2 slc18a2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Vesicular Monoamine Transporter 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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