Rabbit VEGFR1 Polyclonal Antibody | anti-VEGFR1 antibody

VEGFR1 Polyclonal Antibody Cy5 Conjugated

Cat. Num. AAA9459793

• Gene Names: Flt1; VEGFR-1
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence
• Purity: Purified by Protein A
• Synonyms: VEGFR1; Polyclonal Antibody; VEGFR1 Polyclonal Antibody Cy5 Conjugated; VEGFR-1; Vascular endothelial growth factor receptor 1; Fms-like tyrosine kinase 1; FLT-1; Tyrosine-protein kinase receptor FLT; Flt1; Vegfr1; anti-VEGFR1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A
• Form/Format: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
• Concentration: 1mgml (varies by lot)

• Applicable Applications for anti-VEGFR1 antibody: Immunofluorescence (IF)
• Application Notes: IF: 1:50-200
• Conjugation: Cy5
• Excitation Emission: 625,650nm 670nm
• Immunogen: KLH conjugated synthetic peptide aa 1160-1210 1333 derived from rat VEGFR1
• Preparation and Storage: Store at 4 degree C for 12 months.

Related Product Information for anti-VEGFR1 antibody

Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, and proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts. Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to the activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1 ERK2, MAPK3 ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC, YES1 and PLCG, and may also phosphorylate CBL. Promotes phosphorylation of AKT1 and PTK2 FAK1 (By similarity).

Product Categories/Family for anti-VEGFR1 antibody

Conjugated Primary Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 1718161
• NCBI GeneID: 54251
• UniProt Accession #: P53767
• Molecular Weight: 150,250 Da
• NCBI Official Full Name: Vascular endothelial growth factor receptor 1
• NCBI Official Synonym Full Names: FMS-related tyrosine kinase 1
• NCBI Official Symbol: Flt1
• NCBI Official Synonym Symbols: VEGFR-1
• NCBI Protein Information: vascular endothelial growth factor receptor 1; FLT-1; FMS-like tyrosine kinase 1; tyrosine-protein kinase receptor FLT; vascular endothelial growth factor receptor-1; Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability
• UniProt Protein Name: Vascular endothelial growth factor receptor 1
• UniProt Gene Name: Flt1
• UniProt Synonym Gene Names: Flt-1; Vegfr1; VEGFR-1; FLT-1
• UniProt Entry Name: VGFR1_RAT

NCBI Description

tyrosine kinase receptor for vascular endothelial growth factor; may play a role in cell proliferation and cell survival [RGD, Feb 2006]

Uniprot Description

VEGFR1: a receptor tyrosine kinase of the VEGFR family. Receptor for VEGF, VEGFB and PGF. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Two splice variant isoforms have been described. Isoform SFlt1 may have an inhibitory role in angiogenesis.

Protein type: Protein kinase, tyrosine (receptor); Membrane protein, integral; Protein kinase, TK; EC 2.7.10.1; Kinase, protein; TK group; VEGFR family

Cellular Component: focal adhesion; integral to plasma membrane; plasma membrane; receptor complex; endosome

Molecular Function: vascular endothelial growth factor receptor activity; identical protein binding; growth factor binding; transmembrane receptor protein tyrosine kinase activity; receptor signaling protein tyrosine kinase activity; ATP binding

Biological Process: peptidyl-tyrosine phosphorylation; activation of MAPKK activity; protein amino acid autophosphorylation; positive regulation of smooth muscle cell proliferation; chemotaxis; protein amino acid phosphorylation; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of MAP kinase activity; monocyte chemotaxis; positive regulation of fibroblast proliferation; positive regulation of cell proliferation; angiogenesis; embryonic morphogenesis; cell differentiation; regulation of smooth muscle contraction; cell migration; intracellular receptor-mediated signaling pathway; positive regulation of phosphoinositide 3-kinase activity; patterning of blood vessels; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of angiogenesis; response to hypoxia; blood vessel morphogenesis; sprouting angiogenesis; vascular endothelial growth factor receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration