Rabbit anti-Human VDAC3 Polyclonal Antibody | anti-VDAC3 antibody

VDAC3, ID (VDAC3, Voltage-dependent anion-selective channel protein 3, Outer mitochondrial membrane protein porin 3) (AP)

Cat. Num. AAA6362389

• Gene Names: VDAC3; VDAC-3; HD-VDAC3
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: VDAC3; Polyclonal Antibody; ID (VDAC3; Voltage-dependent anion-selective channel protein 3; Outer mitochondrial membrane protein porin 3) (AP); Outer mitochondrial membrane protein porin 3; anti-VDAC3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).
• Sequence Length: 283

• Applicable Applications for anti-VDAC3 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: VDAC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 155-183 amino acids from the Central region of human VDAC3.
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(VDAC3 Antibody (Center) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the VDAC3 antibody detected the VDAC3 protein (arrow).)

Related Product Information for anti-VDAC3 antibody

VDAC3 belongs to a group of mitochondrial membrane channels involved in translocation of adenine nucleotides through the outer membrane. These channels may also function as a mitochondrial binding site for hexokinase (see HK1; MIM 142600) and glycerol kinase (GK; MIM 300474) (Rahmani et al., 1998).[supplied by OMIM].

Product Categories/Family for anti-VDAC3 antibody

Antibodies; Mitochondrial Proteins

References

Reina, S., et al. FEBS Lett. 584(13):2837-2844(2010). Lefievre, L., et al. Proteomics 7(17):3066-3084(2007). Lamesch, P., et al. Genomics 89(3):307-315(2007). Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007): Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005).

NCBI and Uniprot Product Information

• NCBI GI #: 25188179
• NCBI GeneID: 7419
• NCBI Accession #: NP_005653.3; NP_001129166.1
• NCBI GenBank Nucleotide #: NP_005653.3
• UniProt Accession #: Q9Y277
• NCBI Official Full Name: voltage-dependent anion-selective channel protein 3 isoform 1
• NCBI Official Synonym Full Names: voltage dependent anion channel 3
• NCBI Official Symbol: VDAC3
• NCBI Official Synonym Symbols: VDAC-3; HD-VDAC3
• NCBI Protein Information: voltage-dependent anion-selective channel protein 3
• UniProt Protein Name: Voltage-dependent anion-selective channel protein 3
• Protein Family: Voltage-dependent anion-selective channel protein
• UniProt Gene Name: VDAC3
• UniProt Synonym Gene Names: VDAC-3; hVDAC3
• UniProt Entry Name: VDAC3_HUMAN

NCBI Description

This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Uniprot Description

VDAC3: a protein of the eukaryotic mitochondrial porin family. Forms a voltage-dependent anion channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. Two splice-variant isoforms have been described.

Protein type: Channel, misc.; Mitochondrial; Membrane protein, integral

Chromosomal Location of Human Ortholog: 8p11.2

Cellular Component: pore complex; mitochondrial outer membrane; mitochondrion; nucleus

Molecular Function: nucleotide binding; voltage-gated anion channel activity; porin activity

Biological Process: adenine transport; transmembrane transport; anion transport