Goat VCAM1/CD106 Polyclonal Antibody | anti-VCAM1/CD106 antibody

Anti-VCAM1/CD106 Antibody (aa349-362)

Cat. Num. AAA2401034

• Gene Names: VCAM1; CD106; INCAM-100
• Reactivity: Human; Predicted: Monkey
• Applications: ELISA, Immunohistochemistry, Western Blot
• Purity: Immunoaffinity Purified
• Synonyms: VCAM1/CD106; Polyclonal Antibody; Anti-VCAM1/CD106 Antibody (aa349-362); Mouse Monoclonal [clone 1.G11B1] (IgG1) to Human VCAM1/CD106; VCAM1; CD106; CD106 antigen; INCAM-100; V-CAM 1; VCAM-1; anti-VCAM1/CD106 antibody

• Host: Goat
• Reactivity: Human; Predicted: Monkey
• Clonality: Polyclonal
• Specificity: Human VCAM1/VCAM-1/CD106. This antibody is expected to recognize isoform a (NP_001069.1) and isoform c (NP_001186763.1).
• Purity/Purification: Immunoaffinity Purified
• Form/Format: Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
• Sequence Length: 739

• Applicable Applications for anti-VCAM1/CD106 antibody: ELISA (EIA), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
• Application Notes: ELISA: 1:64000; IHC-P: 5 ug/ml; WB: 1-3 ug/ml
• Immunogen: Synthetic peptide C-TQIDSPLSGKVRSE from an internal region of human VCAM1/VCAM-1/CD106 (NP_001069.1; NP_001186763.1). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Elephant (100%); Galago, Horse, Rabbit (93%); Ferret, Panda, Bovine (86%).
• Conjugation: Unconjugated
• Epitope: aa349-362
• Preparation and Storage: Store at -20 degree C.; Avoid freeze-thaw cycles.

Immunohistochemistry (IHC)

(Anti-VCAM1/CD106 antibody IHC staining of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (WB)

(Anti-VCAM1/CD106 antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Western Blot (WB)

(VCAM1 antibody (1 ug/ml) staining of Human Uterus lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)

Related Product Information for anti-VCAM1/CD106 antibody

Vascular cell adhesion molecule 1, VCAM-1, is a surface glycoproteinexpressed by cytokine-activated endothelium that mediates the adhesionof monocytes and lymphocytes. VCAM-1 and integrin alpha-4-beta-1facilitate a critical cell-cell adhesion event required for survival ofendothelial and mural cells during vascularization. Studies of heartdevelopment have shown that deficiencies of VCAM and in alpha-4 integrinalso result in epicardial dissolution and subsequent myocardialthinning.

Product Categories/Family for anti-VCAM1/CD106 antibody

ICAM

NCBI and Uniprot Product Information

• NCBI GI #: 4507875
• NCBI GeneID: 7412
• NCBI Accession #: NP_001069.1
• NCBI GenBank Nucleotide #: NM_001078.3
• UniProt Accession #: P19320; Q6NUP8; A8K6R7; B4DKS4; E9PDD1
• Molecular Weight: 74,346 Da
• NCBI Official Full Name: vascular cell adhesion protein 1 isoform a
• NCBI Official Synonym Full Names: vascular cell adhesion molecule 1
• NCBI Official Symbol: VCAM1
• NCBI Official Synonym Symbols: CD106; INCAM-100
• NCBI Protein Information: vascular cell adhesion protein 1
• UniProt Protein Name: Vascular cell adhesion protein 1
• UniProt Gene Name: VCAM1
• UniProt Synonym Gene Names: V-CAM 1; VCAM-1

NCBI Description

This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010]

Uniprot Description

Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.