Rabbit anti-Human VANGL2 Polyclonal Antibody | anti-VANGL2 antibody

VANGL2 Antibody

Cat. Num. AAA7044402

• Gene Names: VANGL2; LPP1; LTAP; STB1; STBM; STBM1
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Antigen Affinity Purified
• Synonyms: VANGL2; Polyclonal Antibody; VANGL2 Antibody; Vang-like protein 2; Loop-tail protein 1 homolog; Strabismus 1; Van Gogh-like protein 2; KIAA1215; STB1; anti-VANGL2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 521

• Applicable Applications for anti-VANGL2 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Species: Human
• Immunogen: Recombinant human Vang-like protein 2 protein (N-110AA)
• Conjugate: Non-conjugated
• Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-46561 / sc-46560 / sc-67136
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Western Blot (WB)

(Western blotAll lanes: VANGL2 antibody at 2.26ug/mlLane 1: HepG-2 whole cell lysateLane 2: MCF7 whole cell lysateLane 3: Hela whole cell lysateLane 4: NIH/3T3 whole cell lysateSecondaryGoat polyclonal to Rabbit IgG at 1/10000 dilutionPredicted band size: 60 kDaObserved band size: 60 kDa)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human lung cancer using MBS7044402 at dilution 1:100)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human gastric cancer using MBS7044402 at dilution 1:100)

Western Blot (WB)

(Western BlotPositive WB detected in:HepG2 whole cell lysate,MCF-7 whole cell lysate,Mouse kidney tissueAll lanes: Vangl2 antibody at 3ug/mlSecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 60 kDaObserved band size: 60 kDa)

Related Product Information for anti-VANGL2 antibody

Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 62955805
• NCBI GeneID: 57216
• NCBI Accession #: NP_065068.1
• NCBI GenBank Nucleotide #: NM_020335.2
• UniProt Accession #: Q9ULK5; Q5T212; D3DVE9
• Molecular Weight: 59,714 Da
• NCBI Official Full Name: vang-like protein 2
• NCBI Official Synonym Full Names: VANGL planar cell polarity protein 2
• NCBI Official Symbol: VANGL2
• NCBI Official Synonym Symbols: LPP1; LTAP; STB1; STBM; STBM1
• NCBI Protein Information: vang-like protein 2
• UniProt Protein Name: Vang-like protein 2
• Protein Family: Vang-like protein
• UniProt Gene Name: VANGL2
• UniProt Synonym Gene Names: KIAA1215; STB1
• UniProt Entry Name: VANG2_HUMAN

NCBI Description

The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate. [provided by RefSeq, Sep 2011]

Uniprot Description

VANGL2: Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Interacts through its C-terminal region with the N- terminal half of DVL1, DVL2 and DVL3. The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction. Also interacts with the PDZ domains of MAGI3, SCRIB/SCRB1 and FZD3. Belongs to the Vang family.

Protein type: Membrane protein, multi-pass; Adaptor/scaffold; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q22-q23

Cellular Component: apical plasma membrane; intercellular junction; lateral plasma membrane; plasma membrane

Molecular Function: protein binding

Biological Process: apical protein localization; establishment of planar polarity; heart looping; neural tube closure; sensory cilium biogenesis

Disease: Neural Tube Defects