Rabbit anti-Human VANGL1 Polyclonal Antibody | anti-VANGL1 antibody

VANGL1 (Vang-like Protein 1, Van Gogh-like Protein 1, Loop-tail Protein 2 Homolog, LPP2, Strabismus 2, STB2, STBM2, KITENIN) (FITC)

Cat. Num. AAA6398230

• Gene Names: VANGL1; LPP2; STB2; STBM2; KITENIN
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: VANGL1; Polyclonal Antibody; VANGL1 (Vang-like Protein 1; Van Gogh-like Protein 1; Loop-tail Protein 2 Homolog; LPP2; Strabismus 2; STB2; STBM2; KITENIN) (FITC); anti-VANGL1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human VANGL1.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-VANGL1 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human VANGL1, aa1-524 (NP_620409.1).
• Immunogen Sequence: MDTESTYSGYSYYSSHSKKSHRQGERTRERHKSPRNKDGRGSEKSVTIQPPTGEPLLGNDSTRTEEVQDDNWGETTTAITGTSEHSISQEDIARISKDMEDSVGLDCKRYLGLTVASFLGLLVFLTPIAFILLPPILWRDELEPCGTICEGLFISMAFKLLILLIGTWALFFRKRRADMPRVFVFRALLLVLIFLFVVSYWLFYGVRILDSRDRNYQGIVQYAVSLVDALLFIHYLAIVLLELRQLQPMFTLQVVRSTDGESRFYSLGHLSIQRAALVVLENYYKDFTIYNPNLLTASKFRAAKHMAGLKVYNVDGPSNNATGQSRAMIAAAARRRDSSHNELYYEEAEHERRVKKRKARLVVAVEEAFIHIQRLQAEEQQKAPGEVMDPREAAQAIFPSMARALQKYLRITRQQNYHSMESILQHLAFCITNGMTPKAFLERYLSAGPTLQYDKDRWLSTQWRLVSDEAVTNGLRDGIVFVLKCLDFSLVVNVKKIPFIILSEEFIDPKSHKFVLRLQSETSV
• Conjugate: FITC
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(VANGL1 rabbit polyclonal antibody. Western Blot analysis of VANGL1 expression in HeLa.)

Western Blot (WB)

(Western Blot analysis of VANGL1 expression in transfected 293T cell line by VANGL1 polyclonal antibody. Lane 1: VANGL1 transfected lysate (6kD). Lane 2: Non-transfected lysate.)

Product Categories/Family for anti-VANGL1 antibody

Antibodies; Neuroscience

NCBI and Uniprot Product Information

• NCBI GI #: 20373171
• NCBI GeneID: 81839
• NCBI Accession #: NP_620409.1
• NCBI GenBank Nucleotide #: NM_138959.2
• UniProt Accession #: Q8TAA9; Q5T1D3; Q5T1D4; Q86WG8; Q8N559
• Molecular Weight: 59,975 Da
• NCBI Official Full Name: vang-like protein 1 isoform 1
• NCBI Official Synonym Full Names: VANGL planar cell polarity protein 1
• NCBI Official Symbol: VANGL1
• NCBI Official Synonym Symbols: LPP2; STB2; STBM2; KITENIN
• NCBI Protein Information: vang-like protein 1; strabismus 2; van Gogh-like protein 1; loop-tail protein 2 homolog; vang-like 1 (van gogh, Drosophila); KAI1 C-terminal interacting tetraspanin
• UniProt Protein Name: Vang-like protein 1
• Protein Family: Vang-like protein
• UniProt Gene Name: VANGL1
• UniProt Synonym Gene Names: STB2; LPP2
• UniProt Entry Name: VANG1_HUMAN

NCBI Description

This gene encodes a member of the tretraspanin family. The encoded protein may be involved in mediating intestinal trefoil factor induced wound healing in the intestinal mucosa. Mutations in this gene are associated with neural tube defects. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

Uniprot Description

VANGL1: Defects in VANGL1 are a cause of neural tube defects (NTD). NTD are congenital malformations. The most common forms of NTD are described as open defects (including anencephaly and myelomeningocele, or spina bifida), which result from the failure of fusion in the cranial and spinal region of the neural tube, respectively. Other open dysraphisms (including myeloschisis, hemimyelomeningocele, and hemimyelocele) are sometimes associated with a Chiari type 2 malformation. A number of skin-covered (closed) NTD are categorized clinically depending on the presence of a subcutaneous mass (lipomyeloschisis, lipomyelomeningocele, meningocele, and myelocystocele) or the absence of such a mass (complex dysraphic states, including split cord malformations, dermal sinus, caudal regression, and segmental spinal dysgenesis). Defects in VANGL1 are a cause of sacral defect with anterior meningocele (SDAM). SDAM is a form of caudal dysgenesis. It is present at birth and becomes symptomatic later in life, usually because of obstructive labor in females, chronic constipation, or meningitis. Inheritance is autosomal dominant. Belongs to the Vang family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p13.1

Cellular Component: integral to membrane; lateral plasma membrane

Molecular Function: protein binding

Biological Process: multicellular organismal development

Disease: Neural Tube Defects; Sacral Defect With Anterior Meningocele