Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human prostate cancer tissue using at dilution 1/25,)
Rabbit anti-Human USP5 Polyclonal Antibody | anti-USP5 antibody
USP5 Antibody
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human prostate cancer tissue using at dilution 1/25,)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human prostate cancer tissue using at dilution 1/25,)
NCBI and Uniprot Product Information
Uniprot Description
USP5: Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys- 63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition. Belongs to the peptidase C19 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.4.19.12; Protease; Ubiquitin-specific protease
Chromosomal Location of Human Ortholog: 12p13
Cellular Component: lysosome
Molecular Function: cysteine-type endopeptidase activity; protein binding; ubiquitin binding; ubiquitin-specific protease activity
Biological Process: positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination
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Product Notes
The USP5 usp5 (Catalog #AAA9415854) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The USP5 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's USP5 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Immunohistochemistry: 1:25-1:100. Researchers should empirically determine the suitability of the USP5 usp5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "USP5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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