Western Blot (WB)
(USP20 Antibody (Center) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the USP20 antibody detected the USP20 protein (arrow).)
Rabbit USP20 Polyclonal Antibody | anti-USP20 antibody
USP20 Antibody (Center)
Western Blot (WB)
(USP20 Antibody (Center) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the USP20 antibody detected the USP20 protein (arrow).)
Western Blot (WB)
(USP20 Antibody (Center) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the USP20 antibody detected the USP20 protein (arrow).)
Western Blot (WB)
(USP20 Antibody (Center) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the USP20 antibody detected the USP20 protein (arrow).)
Western Blot (WB)
(USP20 Antibody (Center) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the USP20 antibody detected the USP20 protein (arrow).)
Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)
Berthouze, M., et al. EMBO J. 28(12):1684-1696(2009)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Li, Z., et al. EMBO Rep. 6(4):373-378(2005)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a ubiquitin specific processing protease that was first identified as a substrate of the VHL (von Hippel-Lindau disease) protein E3 ubiquitin ligase complex. In addition to being ubiquitinated by the VHL-E3 ligase complex, this enzyme deubiquitinates hypoxia-inducible factor (HIF)-1 alpha and thereby causes increased expression of HIF-1alpha targeted genes which play a role in angiogenesis, glucose metabolism, cell proliferation and metastasis. The enzyme encoded by this gene also regulates G-protein coupled receptor signaling by mediating the deubiquitination of beta-2 adrenergic receptor (ADRB2). This enzyme is a ubiquitously expressed thiolester hydrolase. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jan 2013]
Uniprot Description
USP20: Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the peptidase C19 family. USP20/USP33 subfamily.
Protein type: EC 3.4.19.12; Ubiquitin conjugating system; Protease; Ubiquitin-specific protease
Chromosomal Location of Human Ortholog: 9q34.11
Cellular Component: centrosome; perinuclear region of cytoplasm
Molecular Function: protein binding; G-protein-coupled receptor binding; zinc ion binding; cysteine-type endopeptidase activity; ubiquitin-specific protease activity
Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination; endocytosis; regulation of G-protein coupled receptor protein signaling pathway
Research Articles on USP20
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Product Notes
The USP20 usp20 (Catalog #AAA9215279) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 310-339. The USP20 Antibody (Center) reacts with Human, mouse (Predicted Reactivity: Bovine) and may cross-react with other species as described in the data sheet. AAA Biotech's USP20 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the USP20 usp20 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "USP20, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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