Rabbit anti-Human USP11 Polyclonal Antibody | anti-USP11 antibody

USP11 (Ubiquitin-specific Processing Protease 11, UHX1) (HRP)

Cat. Num. AAA6442714

• Gene Names: USP11; UHX1
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by affinity chromatography.
• Synonyms: USP11; Polyclonal Antibody; USP11 (Ubiquitin-specific Processing Protease 11; UHX1) (HRP); anti-USP11 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human USP11.
• Purity/Purification: Purified by affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).
• Concentration: ~1mg/ml (varies by lot)

• Applicable Applications for anti-USP11 antibody: Immunohistochemistry (IHC), Western Blot (WB)
• Application Notes: IHC: 1:50-1:200; WB: 1:500-1:2000; Applications are based on unconjugated antibody.
• Immunogen: Recombinant protein corresponding to human USP11.
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of extracts of Human testis, using USP11 antibody.)

Product Categories/Family for anti-USP11 antibody

Antibodies; Ubiquitin

NCBI and Uniprot Product Information

• NCBI GI #: 24234683
• NCBI GeneID: 8237
• NCBI Accession #: NP_004642.2
• NCBI GenBank Nucleotide #: NM_004651.3
• UniProt Accession #: P51784; Q8IUG6; Q9BWE1; B2RTX1
• Molecular Weight: 109,817 Da
• NCBI Official Full Name: ubiquitin carboxyl-terminal hydrolase 11
• NCBI Official Synonym Full Names: ubiquitin specific peptidase 11
• NCBI Official Symbol: USP11
• NCBI Official Synonym Symbols: UHX1
• NCBI Protein Information: ubiquitin carboxyl-terminal hydrolase 11; ubiquitin thioesterase 11; deubiquitinating enzyme 11; ubiquitin thiolesterase 11; ubiquitin-specific processing protease 11; ubiquitin-specific-processing protease 11; ubiquitin carboxyl-terminal hydrolase, X-lin
• UniProt Protein Name: Ubiquitin carboxyl-terminal hydrolase 11
• Protein Family: Ubiquitin carboxyl-terminal hydrolase
• UniProt Gene Name: USP11
• UniProt Synonym Gene Names: UHX1
• UniProt Entry Name: UBP11_HUMAN

NCBI Description

Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This gene encodes a deubiquitinating enzyme which lies in a gene cluster on chromosome Xp11.23 [provided by RefSeq, Jul 2008]

Uniprot Description

USP11: Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks. Belongs to the peptidase C19 family.

Protein type: Ubiquitin-specific protease; EC 3.4.19.12; Ubiquitin conjugating system; Protease

Chromosomal Location of Human Ortholog: Xp11.23

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding; cysteine-type endopeptidase activity; ubiquitin-specific protease activity

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination