Rabbit anti-Human, Mouse UQCR10 Polyclonal Antibody | anti-UQCR10 antibody

UQCR10 Antibody

Cat. Num. AAA9630816

• Gene Names: UQCR10; QCR9; UCRC; HSPC051; HSPC119; HSPC151; UCCR7.2
• Reactivity: Human, Mouse
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: UQCR10; Polyclonal Antibody; UQCR10 Antibody; Cytochrome c1 non heme 7 kDa protein; Cytochrome C1 nonheme 7kDa protein; HSPC051; HSPC119; HSPC151; QCR9; Ubiquinol cytochrome c reductase complex; Ubiquinol cytochrome c reductase complex (7.2 kD); Ubiquinol cytochrome c reductase complex 7.2 kDa protein; Ubiquinol cytochrome c reductase complex III subunit X 7.2kDa; Ubiquinol cytochrome c reductase complex III subunit X; UCCR7.2; UCRC; anti-UQCR10 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: UQCR10 Antibody detects endogenous levels of UQCR10.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-UQCR10 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from human UQCR10.
• Conjugation: Unconjugated
• Similarity: Belongs to the UQCR10/QCR9 family.
• Subunit Structure: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1 (By similarity). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
• Function: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-UQCR10 antibody

Mitochondrion inner membrane; Single-pass membrane protein; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 51173876
• NCBI GeneID: 29796
• NCBI Accession #: NP_001003684.1
• NCBI GenBank Nucleotide #: NM_001003684.1
• UniProt Accession #: Q9UDW1; Q9T2V6; B5MCM5
• Molecular Weight: 34.2 kDa
• NCBI Official Full Name: cytochrome b-c1 complex subunit 9 isoform b
• NCBI Official Synonym Full Names: ubiquinol-cytochrome c reductase, complex III subunit X
• NCBI Official Symbol: UQCR10
• NCBI Official Synonym Symbols: QCR9; UCRC; HSPC051; HSPC119; HSPC151; UCCR7.2
• NCBI Protein Information: cytochrome b-c1 complex subunit 9; cytochrome C1, nonheme 7kDa protein; cytochrome c1 non-heme 7 kDa protein; ubiquinol-cytochrome c reductase complex (7.2 kD); ubiquinol-cytochrome c reductase complex 7.2 kDa protein; ubiquinol-cytochrome c reductase, co
• UniProt Protein Name: Cytochrome b-c1 complex subunit 9
• UniProt Gene Name: UQCR10
• UniProt Synonym Gene Names: UCRC
• UniProt Entry Name: QCR9_HUMAN

NCBI Description

UCRC is a subunit of mitochondrial complex III (ubiquinol-cytochrome c reductase; EC 1.10.2.2), which forms the middle segment of the respiratory chain of the inner mitochondrial membrane (Schagger et al., 1995 [PubMed 8592474]).[supplied by OMIM, Mar 2008]

Uniprot Description

UCRC iso3: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit interacts with cytochrome c1. Belongs to the UQCR10/QCR9 family. The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

Protein type: Energy Metabolism - oxidative phosphorylation; Mitochondrial

Chromosomal Location of Human Ortholog: 22q12.2

Cellular Component: mitochondrial inner membrane; mitochondrial respiratory chain complex III

Molecular Function: ubiquinol-cytochrome-c reductase activity

Biological Process: cellular metabolic process; mitochondrial electron transport, ubiquinol to cytochrome c