Rabbit Upstream Transcription Factor-1 Polyclonal Antibody | anti-USF1 antibody
Upstream Transcription Factor-1 (USF1)
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Dilution: ELISA (serum titer): 1:137,500
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq]
Uniprot Description
USF1: Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters. Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as an homodimer or a heterodimer (USF1/USF2). Interacts with varicella-zoster virus IE62 protein.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 1q22-q23
Cellular Component: nucleoplasm; transcription factor complex; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; enzyme binding; protein homodimerization activity; protein heterodimerization activity; sequence-specific DNA binding; histone deacetylase binding; double-stranded DNA binding; bHLH transcription factor binding; protein kinase binding
Biological Process: transcription from RNA polymerase II promoter; lipid homeostasis; glucose metabolic process; late viral mRNA transcription; glucose homeostasis; regulation of transcription from RNA polymerase II promoter; negative regulation of fibrinolysis; cellular response to insulin stimulus; response to hypoxia; regulation of transcription from RNA polymerase II promoter by glucose; regulation of transcription by carbon catabolites; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter by glucose; response to UV
Disease: Hyperlipidemia, Combined, 1
Research Articles on USF1
2. Over-expression of human USF1 in transgenic mice influenced metabolic traits.
3. Defective gene induction of USF1 variant by insulin contributes to the risk of developing dyslipidemia.
4. Reinforce the roles of APOA5 and USF1 variants on cardiovascular phenotypes and suggest that both genes contribute to lipid levels and aortic atherosclerosis individually and possibly through epistatic effects.
5. USF1 and FADS3 are causal candidate genes for the Mexican familial combined hyperlipidemia.
6. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
7. a novel signaling pathway inhibits hepatic gluconeogenesis through HGF/AMPK/USF-1/SHP
8. USF1 and USF2 regulate transcriptional activity of the FOXE1 promoter.
9. USF-1 specificity is directed via p38-mediated phosphorylation-dependent acetylation
10. both USF1 and USF2 bind to an E-box sequence located in the OCT1 core promoter region and are required for the basal gene expression of this transporter.
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Product Notes
The USF1 usf1 (Catalog #AAA611538) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Upstream Transcription Factor-1 (USF1) reacts with Human, Rodent and may cross-react with other species as described in the data sheet. AAA Biotech's Upstream Transcription Factor-1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Immunohistochemistry (IHC). Suitable for use in ELISA and Immunohistochemistry. Dilution: ELISA (serum titer): 1:137,500. Researchers should empirically determine the suitability of the USF1 usf1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Upstream Transcription Factor-1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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