Rabbit anti-Human UPK3B Polyclonal Antibody | anti-UPK3B antibody

UPK3B, ID (UPK3B, Uroplakin-3b, Uroplakin IIIb, p35) (AP)

Cat. Num. AAA6361641

• Gene Names: UPK3B; P35; UP3B; UPIIIB
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A and Peptide Affinity Chromatography.
• Synonyms: UPK3B; Polyclonal Antibody; ID (UPK3B; Uroplakin-3b; Uroplakin IIIb; p35) (AP); p35; anti-UPK3B antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human UPK3B.
• Purity/Purification: Purified by Protein A and Peptide Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

• Applicable Applications for anti-UPK3B antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 192-219 in the central region of human UPK3B, UniProt Accession #Q9BT76.
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in Jurkat cell line lysates (35ug/lane) usingMBS6007132. This demonstrates that MBS6007132 detected the UPK3B protein (arrow).)

Related Product Information for anti-UPK3B antibody

UPK3B is a minor component of the apical plaques of mammalian urothelium that binds and dimerizes with uroplakin-1b (UPK1B; MIM 602380), one of the major conserved urothelium membrane proteins. The other major conserved integral membrane proteins of urothelial plaques are UPK1A (MIM 611557), UPK2 (MIM 611558), and UPK3A (MIM 611559) (Deng et al., 2002 [PubMed 12446744]).[supplied by OMIM].

Product Categories/Family for anti-UPK3B antibody

Antibodies; Proteins

References

1. Foot, N.J., et al. Blood 112(10):4268-4275(2008). 2. Lamesch, P., et al. Genomics 89(3):307-315(2007). 3. Garcia-Espana, A., et al. Mol. Phylogenet. Evol. 41(2):355-367(2006). 4. Deng, F.M., et al. J. Cell Biol. 159(4):685-694(2002).

NCBI and Uniprot Product Information

• NCBI GI #: 13399330
• NCBI GeneID: 80761
• NCBI Accession #: NP_085047.1
• NCBI GenBank Nucleotide #: NM_030570.2
• UniProt Accession #: Q9BT76; Q75MM5; Q86W06; A8K231; A8MZA8; B3KPU5
• Molecular Weight: 33,882 Da
• NCBI Official Full Name: uroplakin-3b isoform a
• NCBI Official Synonym Full Names: uroplakin 3B
• NCBI Official Symbol: UPK3B
• NCBI Official Synonym Symbols: P35; UP3B; UPIIIB
• NCBI Protein Information: uroplakin-3b; uroplakin IIIb
• UniProt Protein Name: Uroplakin-3b
• Protein Family: Uroplakin
• UniProt Gene Name: UPK3B
• UniProt Synonym Gene Names: UP3b; UPIIIb
• UniProt Entry Name: UPK3B_HUMAN

NCBI Description

UPK3B is a minor component of the apical plaques of mammalian urothelium that binds and dimerizes with uroplakin-1b (UPK1B; MIM 602380), one of the major conserved urothelium membrane proteins. The other major conserved integral membrane proteins of urothelial plaques are UPK1A (MIM 611557), UPK2 (MIM 611558), and UPK3A (MIM 611559) (Deng et al., 2002 [PubMed 12446744]).[supplied by OMIM, Mar 2008]

Uniprot Description

UPK3B: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence. Belongs to the uroplakin-3 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q11.2

Cellular Component: plasma membrane; integral to membrane