Western Blot (WB)
(Anti- Unrip Picoband antibody, MBS177676, Western blottingAll lanes: Anti Unrip (MBS177676) at 0.5ug/mlLane 1: Rat Brain Tissue Lysate at 50ugLane 2: HEPG2 Whole Cell Lysate at 40ugLane 3: SMMC Whole Cell Lysate at 40ugLane 4: U87 Whole Cell Lysate at 40ugLane 5: Human Placenta Tissue Lysate at 50ugLane 6: HELA Whole Cell Lysate at 40ugPredicted bind size: 38KDObserved bind size: 38KD)
anti-Human, Rat Unrip Polyclonal Antibody | anti-STRAP antibody
Anti-Unrip Antibody
Immunohistochemistry (IHC) Paraffin Concentration: 0.5-1ug/ml
Western Blot (WB)
(Anti- Unrip Picoband antibody, MBS177676, Western blottingAll lanes: Anti Unrip (MBS177676) at 0.5ug/mlLane 1: Rat Brain Tissue Lysate at 50ugLane 2: HEPG2 Whole Cell Lysate at 40ugLane 3: SMMC Whole Cell Lysate at 40ugLane 4: U87 Whole Cell Lysate at 40ugLane 5: Human Placenta Tissue Lysate at 50ugLane 6: HELA Whole Cell Lysate at 40ugPredicted bind size: 38KDObserved bind size: 38KD)
Western Blot (WB)
(Anti- Unrip Picoband antibody, MBS177676, Western blottingAll lanes: Anti Unrip (MBS177676) at 0.5ug/mlLane 1: Rat Brain Tissue Lysate at 50ugLane 2: HEPG2 Whole Cell Lysate at 40ugLane 3: SMMC Whole Cell Lysate at 40ugLane 4: U87 Whole Cell Lysate at 40ugLane 5: Human Placenta Tissue Lysate at 50ugLane 6: HELA Whole Cell Lysate at 40ugPredicted bind size: 38KDObserved bind size: 38KD)
Immunohistochemistry (IHC)
(Anti- Unrip Picoband antibody, MBS177676, IHC(P)IHC(P): Human Mammary Cancer Tissue )
Immunohistochemistry (IHC)
(Anti- Unrip Picoband antibody, MBS177676, IHC(P)IHC(P): Human Mammary Cancer Tissue )
Background: Unrip is also known as STRAP(Serine-threonine kinase receptor-associated protein). It is anenzyme that in humans is encoded by the STRAP gene. It is mapped to 12p12.3. UNRIP is integrated into a complex with UNR or with the SMN complex in vivo in a mutually exclusive manner. It is concluded that UNRIP is the first component of the uridine-rich snRNP assembly machinery that associates with the SMN complex in a compartment-specific way, and it may play a crucial role in the intracellular distribution of the SMN complex.
NCBI and Uniprot Product Information
Uniprot Description
STRAP: The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. STRAP may play a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Binds directly to GEMIN6 and GEMIN7. Associates with the complex in the cytoplasm but not in the nucleus. Also interacts with CSDE1/UNR and MAWBP. Interacts with PDPK1. Belongs to the WD repeat STRAP family.
Protein type: Adaptor/scaffold; RNA splicing
Chromosomal Location of Human Ortholog: 12p12.3
Cellular Component: cytoplasm; cytosol; nucleus; SMN complex
Molecular Function: protein binding; receptor binding
Biological Process: maintenance of gastrointestinal epithelium; negative regulation of epithelial cell proliferation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; spliceosomal snRNP biogenesis
Research Articles on STRAP
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Product Notes
The STRAP strap (Catalog #AAA177676) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-Unrip Antibody reacts with Human, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Unrip can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. Western Blot Concentration: 0.1-0.5ug/ml Immunohistochemistry (IHC) Paraffin Concentration: 0.5-1ug/ml. Researchers should empirically determine the suitability of the STRAP strap for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Unrip, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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