Rabbit UNG2 Polyclonal Antibody | anti-UNG2 antibody

UNG2 Antibody

Cat. Num. AAA9401368

• Gene Names: CCNO; CCNU; UDG2; CILD29
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: Affinity chromatography purified via peptide column
• Synonyms: UNG2; Polyclonal Antibody; UNG2 Antibody; Uracil-DNA glycosylase 2; UDG2; anti-UNG2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 350

• Applicable Applications for anti-UNG2 antibody: ELISA (EIA), Western Blot (WB)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 13 amino acid peptide from near the center of human UNG2.
• Target Name: UNG2
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of UNG2 in human bladder tissue lysate with UNG2 antibody at (A) 1 and (B) 2 ug/mL.)

Related Product Information for anti-UNG2 antibody

The human uracil-DNA glycosylase (UNG) gene encodes both mitochondrial (UNG1) and nuclear (UNG2) forms through differentially regulated promotes and alternative splicing. UNG2 is the major enzyme in the base excision repair pathway that removes uracil residues from DNA that arise through either misincorporation during replication or cytosine deamination. UNG2 can also be bound by the HIV-1 integrase and incorporated into the virion particle, suggesting that it is required to remove uracils from the viral genome. As the intrinsic antiviral protein APOBEC3G generates numerous uracils in the HIV genome during its replication, it may be that the UNG2 contributes to the APOBEC3G-mediated loss of infectivity by generating abasic sites in the viral genome. This UNG2 antibody will not cross-react with UNG1.

Product Categories/Family for anti-UNG2 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 153791755
• NCBI GeneID: 10309
• NCBI Accession #: NP_066970
• NCBI GenBank Nucleotide #: NM_021147.4
• Molecular Weight: 14,297 Da
• NCBI Official Full Name: cyclin-O
• NCBI Official Synonym Full Names: cyclin O
• NCBI Official Symbol: CCNO
• NCBI Official Synonym Symbols: CCNU; UDG2; CILD29
• NCBI Protein Information: cyclin-O
• UniProt Protein Name: Cyclin-O
• Protein Family: Uracil-DNA glycosylase
• UniProt Gene Name: CCNO
• UniProt Entry Name: CCNO_HUMAN

NCBI Description

This gene encodes a member of the cyclin protein family, and the encoded protein is involved in regulation of the cell cycle. Disruption of this gene is associated with primary ciliary dyskinesia-19. Alternative splicing results in multiple transcript variants. This gene, which has a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase in PubMed ID: 2001396. A later publication, PubMed ID: 8419333, identified this gene's product as a cyclin protein family member. The UNG2 symbol is also used as a specific protein isoform name for the UNG gene (GeneID 7374), so confusion exists in the scientific literature and in some databases for these two genes. [provided by RefSeq, Jul 2014]

Uniprot Description

CCNO: This gene, which has a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase in PubMed ID: 2001396. A later publication, PubMed ID: 8419333, identified this gene's product as a cyclin protein family member. The UNG2 term is also used as a specific protein isoform name for the UNG gene (GeneID 7374), so confusion exists in the scientific literature and in some databases for these two genes.[provided by RefSeq, Nov 2010]

Protein type: DNA repair, damage; Cell cycle regulation; Hydrolase; EC 3.2.2.-

Chromosomal Location of Human Ortholog: 5q11.2

Cellular Component: nucleoplasm; cytoplasm

Molecular Function: uracil DNA N-glycosylase activity

Biological Process: response to drug; cell division; base-excision repair; cilium biogenesis; cell cycle

Disease: Ciliary Dyskinesia, Primary, 29