Rabbit anti-Human, Mouse UNCX Polyclonal Antibody | anti-UNCX antibody

UNCX Polyclonal Antibody

Cat. Num. AAA2561493

• Gene Names: UNCX; UNCX4.1
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, ELISA
• Purity: Antigen Affinity Purification
• Synonyms: UNCX; Polyclonal Antibody; UNCX Polyclonal Antibody; Homeobox protein unc-4 homolog; Homeobox protein Uncx4.1; Tcag7.1272; UNC homeobox; Unc4.1 homeobox; UNC4; Uncx; UNCX4.1; anti-UNCX antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purification
• Form/Format: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
• Concentration: 0.4mg/mL (varies by lot)
• Sequence Length: 531

• Applicable Applications for anti-UNCX antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:25-1:100; ELISA: 1:5000-1:10000
• Immunogen: Synthetic peptide of human UNCX
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using UNCX Polyclonal Antibody at dilution of 1:25(×200))

Related Product Information for anti-UNCX antibody

UNCX (UNC homeobox), also known as UNCX4.1, is a 531 amino acid nuclear transcription factor involved in neurogenesis and somitogenesis. Containing one homeobox DNA-binding domain, UNCX belongs to the paired homeobox family and UNC4 subfamily. UNCX assists in the formation of connections between hypothalamic neurons and the pituitary, which is necessary for central neurons to deliver hormones into peripheral blood. UNCX also plays a role in maintaining differentiation of the axial skeleton and acts upstream of Pax-9. The gene encoding UNCX maps to human chromosome 7, which houses over 1, 000 genes and comprises nearly 5% of the human genome. Chromosome 7 has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome.

Product Categories/Family for anti-UNCX antibody

Epigenetics and Nuclear Signaling; Neuroscience

NCBI and Uniprot Product Information

• NCBI GI #: 122937321
• NCBI GeneID: 340260
• NCBI Accession #: NP_001073930.1
• NCBI GenBank Nucleotide #: NP_001073930.1
• UniProt Accession #: A6NJT0
• NCBI Official Full Name: homeobox protein unc-4 homolog
• NCBI Official Synonym Full Names: UNC homeobox
• NCBI Official Symbol: UNCX
• NCBI Official Synonym Symbols: UNCX4.1
• NCBI Protein Information: homeobox protein unc-4 homolog
• UniProt Protein Name: Homeobox protein unc-4 homolog
• Protein Family: Homeobox protein
• UniProt Gene Name: UNCX
• UniProt Synonym Gene Names: UNCX4.1

NCBI Description

This gene encodes a homeobox transcription factor that is involved in somitogenesis and neurogenesis and is required for the maintenance and differentiation of specific elements of the axial skeleton. This gene also plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and deliver hormones that control peripheral functions. The expression of this gene is associated with an increased frequency of acute myeloid leukemia. [provided by RefSeq, Jul 2017]

Uniprot Description

Transcription factor involved in somitogenesis and neurogenesis. Required for the maintenance and differentiation of particular elements of the axial skeleton. May act upstream of PAX9. Plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and to deliver hormones for control of peripheral functions ().