Rabbit anti-Human UNC5C Polyclonal Antibody | anti-UNC5C antibody

UNC5C, NT (UNC5C, UNC5H3, Netrin receptor UNC5C, Protein unc-5 homolog 3, Protein unc-5 homolog C) (PE)

Cat. Num. AAA6361486

• Gene Names: UNC5C; UNC5H3
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: UNC5C; Polyclonal Antibody; NT (UNC5C; UNC5H3; Netrin receptor UNC5C; Protein unc-5 homolog 3; Protein unc-5 homolog C) (PE); Protein unc-5 homolog C; anti-UNC5C antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-UNC5C antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: UNC5C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88-117 amino acids from the N-terminal region of human UNC5C.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(UNC5C Antibody (N-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the UNC5C antibody detected the UNC5C protein (arrow).)

Related Product Information for anti-UNC5C antibody

Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity).

Product Categories/Family for anti-UNC5C antibody

Antibodies; Netrin

NCBI and Uniprot Product Information

• NCBI GI #: 16933525
• NCBI GeneID: 8633
• NCBI Accession #: NP_003719.2
• NCBI GenBank Nucleotide #: NM_003728.2
• UniProt Accession #: O95185; Q8IUT0
• Molecular Weight: 66,079 Da
• NCBI Official Full Name: netrin receptor UNC5C
• NCBI Official Synonym Full Names: unc-5 homolog C (C. elegans)
• NCBI Official Symbol: UNC5C
• NCBI Official Synonym Symbols: UNC5H3
• NCBI Protein Information: netrin receptor UNC5C; unc-5 homolog 3; protein unc-5 homolog 3; protein unc-5 homolog C; unc5 (C.elegans homolog) c
• UniProt Protein Name: Netrin receptor UNC5C
• Protein Family: UNC5C-like protein
• UniProt Gene Name: UNC5C
• UniProt Synonym Gene Names: UNC5H3
• UniProt Entry Name: UNC5C_HUMAN

NCBI Description

This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq, Jul 2008]

Uniprot Description

UNC5C: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Belongs to the unc-5 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 4q21-q23

Cellular Component: integral to membrane; plasma membrane

Molecular Function: netrin receptor activity

Biological Process: axon guidance; apoptosis; positive regulation of apoptosis; brain development; regulation of cell migration; anterior/posterior axon guidance