Hemagglutinin Recombinant Protein | HA recombinant protein

Recombinant Influenza A virus (strain A/Mallard/New York/6750/1978 H2N2) Hemagglutinin

Cat. Num. AAA1457639

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Hemagglutinin; Recombinant Influenza A virus (strain A/Mallard/New York/6750/1978 H2N2) Hemagglutinin; Cleaved into the following 2 chains: 1. Hemagglutinin HA1 chain; 2. Hemagglutinin HA2 chain; HA recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 16-339aa; Partial
• Sequence: DQICIGYHANNSTEKVDTILERNVTVTHAKDILEKTHNGKLCRLSGIPPLELGDCSIAGWLLGNPECDRLLSVPEWSYIVEKENPANGLCYPGNFNDYEELKHLLTRVTHFEKIKILPRDQWTQHTTTGGSRACAVSGNPSFFRNMVWLTKKGSNYPVAKGSYNNTSGEQMLVIWGIHHPNDDTEQRTLYQNVGTYVSVGTSTLNKRSIPEIATRPKVNGQGGRMEFSWTLLETWDVINFESTGNLIAPEYGFKISKRGSSGIMKTEKTLENCETKCQTPLGAINTTLPFHNIHPLTIGECPKYVKSDRLVLATGLRNVPQIES
• Sequence Length: 562

• Species: Influenza A virus (strain A/Mallard/New York/6750/1978 H2N2)
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

SDS-PAGE

Related Product Information for HA recombinant protein

Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore

Product Categories/Family for HA recombinant protein

Microbiology

References

"Origin of the pandemic 1957 H2 influenza A virus and the persistence of its possible progenitors in the avian reservoir." Schafer J.R., Kawaoka Y., Bean W.J., Suss J., Senne D., Webster R.G. Virology 194:781-788(1993)

NCBI and Uniprot Product Information

• NCBI GI #: 82020754
• UniProt Accession #: Q67282
• Molecular Weight: 52.2 kDa
• NCBI Official Full Name: Hemagglutinin
• UniProt Protein Name: Hemagglutinin
• Protein Family: Hemagglutinin
• UniProt Gene Name: HA
• UniProt Entry Name: HEMA_I78A3

Uniprot Description

Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore ().