Rabbit anti-Human UNC45B Polyclonal Antibody | anti-UNC45B antibody

UNC45B Antibody

Cat. Num. AAA9417036

• Gene Names: UNC45B; CMYA4; UNC45; CTRCT43; SMUNC45; UNC-45B
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: UNC45B; Polyclonal Antibody; UNC45B Antibody; CMYA4; UNC45; CTRCT43; SMUNC45; UNC-45B; anti-UNC45B antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total UNC45B protein.
• Purity/Purification: Antigen affinity purification
• Form/Format: Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
• Concentration: 1.6mg/ml (varies by lot)
• Sequence Length: 929

• Applicable Applications for anti-UNC45B antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1: 100-300
• Immunogen: Fusion protein of human UNC45B
• Immunogen Type: Protein
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using UNC45B Antibody at dilution 1/100, on the right is treated with fusion protein. (Original magnification: x200))

Related Product Information for anti-UNC45B antibody

This gene encodes a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function that is conserved in all Unc-45 proteins, and a C-terminal Unc-45/Cro1/She4 domain. The protein is expressed at high levels in striated muscle, where its muscle myosin chaperone activity is dependent on heat shock protein 90 acting as a co-chaperone. A missense mutation in this gene has been associated with cataract development. Alternative splicing results in multiple transcript variants.

Product Categories/Family for anti-UNC45B antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 75750484
• NCBI GeneID: 146862
• NCBI Accession #: NP_001028748.1
• NCBI GenBank Nucleotide #: NM_001033576.1
• UniProt Accession #: Q8IWX7; Q495Q8; Q495Q9
• Molecular Weight: 103,605 Da
• NCBI Official Full Name: protein unc-45 homolog B isoform 2
• NCBI Official Synonym Full Names: unc-45 myosin chaperone B
• NCBI Official Symbol: UNC45B
• NCBI Official Synonym Symbols: CMYA4; UNC45; CTRCT43; SMUNC45; UNC-45B
• NCBI Protein Information: protein unc-45 homolog B
• UniProt Protein Name: Protein unc-45 homolog B
• Protein Family: Protein
• UniProt Gene Name: UNC45B
• UniProt Synonym Gene Names: CMYA4; UNC45; Unc-45B
• UniProt Entry Name: UN45B_HUMAN

NCBI Description

This gene encodes a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function that is conserved in all Unc-45 proteins, and a C-terminal Unc-45/Cro1/She4 domain. The protein is expressed at high levels in striated muscle, where its muscle myosin chaperone activity is dependent on heat shock protein 90 acting as a co-chaperone. A missense mutation in this gene has been associated with cataract development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Uniprot Description

UNC45B: Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: cytoplasm

Molecular Function: protein binding

Biological Process: lens development in camera-type eye

Disease: Cataract 43