Western Blot (WB)
(Western blot analysis of anti-ULK3 Antibody (N-term) in mouse heart tissue lysates (35ug/lane).ULK3(arrow) was detected using the purified Pab.)
Rabbit anti-Human ULK3 Polyclonal Antibody | anti-ULK3 antibody
ULK3, NT (Serine/Threonine-protein Kinase ULK3, Unc-51-like Kinase 3) (MaxLight 405)
FLISA: 1:1,000
WB: 1:50-1:100
Applications are based on unconjugated antibody.
Western Blot (WB)
(Western blot analysis of anti-ULK3 Antibody (N-term) in mouse heart tissue lysates (35ug/lane).ULK3(arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of anti-ULK3 Antibody (N-term) in mouse heart tissue lysates (35ug/lane).ULK3(arrow) was detected using the purified Pab.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human testis tissue reacted with *ULK3 antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human testis tissue reacted with *ULK3 antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
NCBI and Uniprot Product Information
Observed: 52 kDa
Uniprot Description
ULK3: Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Kinase, protein; Other group; ULK family
Chromosomal Location of Human Ortholog: 15q24.1
Cellular Component: membrane; cytoplasm; cytosol
Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding
Biological Process: negative regulation of smoothened signaling pathway; protein amino acid autophosphorylation; positive regulation of smoothened signaling pathway; autophagy; regulation of autophagy; autophagic vacuole formation
Research Articles on ULK3
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Product Notes
The ULK3 ulk3 (Catalog #AAA6504809) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ULK3, NT (Serine/Threonine-protein Kinase ULK3, Unc-51-like Kinase 3) (MaxLight 405) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ULK3 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), FLISA, Western Blot (WB). IHC: 1:10-1:50 FLISA: 1:1,000 WB: 1:50-1:100 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the ULK3 ulk3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ULK3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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