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Goat UHMK1 Polyclonal Antibody | anti-UHMK1 antibody

Goat anti-UHMK1 Antibody

Gene Names
UHMK1; KIS; KIST; P-CIP2
Reactivity
Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
Applications
ELISA
Purity
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Synonyms
UHMK1; Polyclonal Antibody; Goat anti-UHMK1 Antibody; U2AF homology motif (UHM) kinase 1; KIS; Kist; KIS protein kinase; OTTHUMP00000029529; kinase interacting stathmin; kinase interacting with leukemia-associated gene (stathmin); UHMK1 antibody; U2AF homology motif (UHM) kinase 1 antibody; KIS antibody; Kist antibody; KIS protein kinase antibody; OTTHUMP00000029529 antibody; kinase interacting stathmin antibody; kinase interacting with leukemia-associated gene (stathmin) antibody; anti-UHMK1 antibody
Ordering
For Research Use Only!
Host
Goat
Reactivity
Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
Clonality
Polyclonal
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (varies by lot)
Sequence
AGDSKAAQKLLTGR
Sequence Length
419
Applicable Applications for anti-UHMK1 antibody
Peptide ELISA (EIA)
Application Notes
Peptide ELISA: Antibody detection limit dilution 1: 2000.
Western Blot: Preliminary experiments in Human Brain (Cerebellum, Hippocampus and Substantia nigra) lysates gave no specific signal but low background (at antibody concentration up to 1ug/ml).
Immunogen
Peptide with sequence C-AGDSKAAQKLLTGR, from the C-Terminus (near) of the protein sequence according to NP_787062.1.
Epitope
C-Terminus (near)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
39,044 Da
NCBI Official Full Name
serine/threonine-protein kinase Kist isoform 1
NCBI Official Synonym Full Names
U2AF homology motif (UHM) kinase 1
NCBI Official Symbol
UHMK1
NCBI Official Synonym Symbols
KIS; KIST; P-CIP2
NCBI Protein Information
serine/threonine-protein kinase Kist
UniProt Protein Name
Serine/threonine-protein kinase Kist
UniProt Gene Name
UHMK1
UniProt Synonym Gene Names
KIS; KIST; P-CIP2
UniProt Entry Name
UHMK1_HUMAN

NCBI Description

The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Uniprot Description

KIS: a unique kinase that possesses an RNP type RNA-recognition motif (RRM). A proline-directed kinase with a specificity different from the MAP kinases and CDKs. May be involved in trafficking and/or processing of RNA.

Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Kinase, protein; EC 2.7.11.1; Other group; Other-Unique family

Chromosomal Location of Human Ortholog: 1q23.3

Cellular Component: axon; dendrite cytoplasm; nucleus

Molecular Function: ATP binding; mRNA binding; protein binding; protein serine/threonine kinase activity; ribonucleoprotein binding; transferase activity

Biological Process: cell cycle arrest; mRNA catabolic process, nonsense-mediated decay; neurite development; peptidyl-serine phosphorylation; positive regulation of translational initiation; protein amino acid autophosphorylation; regulation of alternative nuclear mRNA splicing, via spliceosome; regulation of protein export from nucleus

Research Articles on UHMK1

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Product Notes

The UHMK1 uhmk1 (Catalog #AAA422262) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-UHMK1 Antibody reacts with Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow and may cross-react with other species as described in the data sheet. AAA Biotech's UHMK1 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA). Peptide ELISA: Antibody detection limit dilution 1: 2000. Western Blot: Preliminary experiments in Human Brain (Cerebellum, Hippocampus and Substantia nigra) lysates gave no specific signal but low background (at antibody concentration up to 1ug/ml). Researchers should empirically determine the suitability of the UHMK1 uhmk1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: AGDSKAAQKL LTGR. It is sometimes possible for the material contained within the vial of "UHMK1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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