Western Blot (WB)
(Western Blot analysis of extracts of rat skin cells, using UCN2 antibody.)
Rabbit UCN2 Polyclonal Antibody | anti-UCN2 antibody
UCN2 Polyclonal Antibody
Gene Names
UCN2; UR; SRP; URP; UCNI; UCN-II
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Immunohistochemistry, Immunofluorescence
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Synonyms
UCN2; Polyclonal Antibody; UCN2 Polyclonal Antibody; Urocortin-2; Stresscopin-related peptide; Urocortin II; Ucn II; Urocortin-related peptide; SRP; URP; anti-UCN2 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
UCN2 polyclonal antibody detects endogenous levels of UCN2 protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Form/Format
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Sequence Length
112
Applicable Applications for anti-UCN2 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes
WB: 1:500-1:2000
IHC: 1:50-1:200
IF: 1:50-1:200
IHC: 1:50-1:200
IF: 1:50-1:200
Immunogen
Recombinant full length Human UCN2.
Preparation and Storage
Store at 4 degree C short term.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Western Blot (WB)
(Western Blot analysis of extracts of rat skin cells, using UCN2 antibody.)
Western Blot (WB)
(Western Blot analysis of extracts of rat skin cells, using UCN2 antibody.)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded mouse heart using UCN2 antibody at dilution of 1:100 (40x lens).)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded mouse heart using UCN2 antibody at dilution of 1:100 (40x lens).)
Immunofluorescence (IF)
(Immunofluorescence analysis of U2OS cell using UCN2 antibody. Blue: DAPI for nuclear staining.)
Immunofluorescence (IF)
(Immunofluorescence analysis of U2OS cell using UCN2 antibody. Blue: DAPI for nuclear staining.)
Related Product Information for anti-UCN2 antibody
Two major regulatory peptides were originally isolated from fish urophysial extracts, Urotensin I and II. In both frog and human, the Urotensin II sequence is located at the carboxy-terminal position of the precursor. Human Urotensin II is composed of only 11 amino acid residues, while fish and frog Urotensin II possess 12 and 13 amino acid residues, respectively. The cyclic region of Urotensin II, which is responsible for the biological activity of the peptide, has been fully conserved from fish to human. However, several substitutions have occurred in the amino-terminal region of the molecule. A human G protein-coupled receptor, GPR14, is the Urotensin II receptor. Human Urotensin II is found within both vascular and cardiac tissue, including coronary atheroma, and effectively constricts isolated arteries from nonhuman primates. Urotensin II may act as an autocrine and/or paracrine hormone rather than as a circulating hormone, by playing an important role in the development of ventricular hypertrophy induced by chronic hypoxia.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
~ 12kDa
NCBI Official Full Name
urocortin-2 preproprotein
NCBI Official Synonym Full Names
urocortin 2
NCBI Official Symbol
UCN2
NCBI Official Synonym Symbols
UR; SRP; URP; UCNI; UCN-II
NCBI Protein Information
urocortin-2
UniProt Protein Name
Urocortin-2
Protein Family
UniProt Gene Name
UCN2
UniProt Synonym Gene Names
SRP; URP; Ucn II
NCBI Description
This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. [provided by RefSeq, Jul 2008]
Uniprot Description
Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.
Research Articles on UCN2
Similar Products
Product Notes
The UCN2 ucn2 (Catalog #AAA3011602) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The UCN2 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's UCN2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). WB: 1:500-1:2000 IHC: 1:50-1:200 IF: 1:50-1:200. Researchers should empirically determine the suitability of the UCN2 ucn2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "UCN2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
