Rabbit UCN2 Polyclonal Antibody | anti-UCN2 antibody
UCN2 Polyclonal Antibody
Gene Names
UCN2; UR; SRP; URP; UCNI; UCN-II
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Immunohistochemistry, Immunofluorescence
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Synonyms
UCN2; Polyclonal Antibody; UCN2 Polyclonal Antibody; Urocortin-2; Stresscopin-related peptide; Urocortin II; Ucn II; Urocortin-related peptide; SRP; URP; anti-UCN2 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
UCN2 polyclonal antibody detects endogenous levels of UCN2 protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Form/Format
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Sequence Length
112
Applicable Applications for anti-UCN2 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes
WB: 1:500-1:2000
IHC: 1:50-1:200
IF: 1:50-1:200
IHC: 1:50-1:200
IF: 1:50-1:200
Immunogen
Recombinant full length Human UCN2.
Preparation and Storage
Store at 4 degree C short term.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Western Blot (WB)
(Western Blot analysis of extracts of rat skin cells, using UCN2 antibody.)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded mouse heart using UCN2 antibody at dilution of 1:100 (40x lens).)
Immunofluorescence (IF)
(Immunofluorescence analysis of U2OS cell using UCN2 antibody. Blue: DAPI for nuclear staining.)
Related Product Information for anti-UCN2 antibody
Two major regulatory peptides were originally isolated from fish urophysial extracts, Urotensin I and II. In both frog and human, the Urotensin II sequence is located at the carboxy-terminal position of the precursor. Human Urotensin II is composed of only 11 amino acid residues, while fish and frog Urotensin II possess 12 and 13 amino acid residues, respectively. The cyclic region of Urotensin II, which is responsible for the biological activity of the peptide, has been fully conserved from fish to human. However, several substitutions have occurred in the amino-terminal region of the molecule. A human G protein-coupled receptor, GPR14, is the Urotensin II receptor. Human Urotensin II is found within both vascular and cardiac tissue, including coronary atheroma, and effectively constricts isolated arteries from nonhuman primates. Urotensin II may act as an autocrine and/or paracrine hormone rather than as a circulating hormone, by playing an important role in the development of ventricular hypertrophy induced by chronic hypoxia.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
~ 12kDa
NCBI Official Full Name
urocortin-2 preproprotein
NCBI Official Synonym Full Names
urocortin 2
NCBI Official Symbol
UCN2
NCBI Official Synonym Symbols
UR; SRP; URP; UCNI; UCN-II
NCBI Protein Information
urocortin-2
UniProt Protein Name
Urocortin-2
Protein Family
UniProt Gene Name
UCN2
UniProt Synonym Gene Names
SRP; URP; Ucn II
NCBI Description
This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. [provided by RefSeq, Jul 2008]
Uniprot Description
Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.
