Rabbit UCN / Urocortin Polyclonal Antibody | anti-UCN antibody

Rabbit Polyclonal (IgG) to Human UCN / Urocortin

Cat. Num. AAA244697

• Gene Names: UCN; UI; UROC
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: UCN / Urocortin; Polyclonal Antibody; Rabbit Polyclonal (IgG) to Human UCN / Urocortin; Anti-UCN / Urocortin Antibody (aa71-120) IHC-plus; UCN; Urocortin; Urocortin I; preproprotein; UI; UROC; Human UCN; anti-UCN antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Urocortin Antibody detects endogenous levels of total Urocortin protein.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 124

• Applicable Applications for anti-UCN antibody: Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
• Application Notes: ELISA (1:5000), IHC-P (5 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic peptide from human Urocortin (aa71-120).
• Immunogen: UCN / Urocortin antibody was raised against synthetic peptide from human Urocortin (aa71-120).
• Antigen Modification: aa71-120
• Preparation and Storage: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.

Immunohistochemistry (IHC)

(Anti-UCN / Urocortin antibody IHC of human testis, Leydig cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Immunohistochemistry (IHC)

(Anti-UCN / Urocortin antibody IHC of human testis, sertoli cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 4507803
• NCBI GeneID: 7349
• NCBI Accession #: NP_003344.1
• NCBI GenBank Nucleotide #: NM_003353.2
• UniProt Accession #: P55089; Q6FG64
• Molecular Weight: 13,458 Da
• NCBI Official Full Name: urocortin preproprotein
• NCBI Official Synonym Full Names: urocortin
• NCBI Official Symbol: UCN
• NCBI Official Synonym Symbols: UI; UROC
• NCBI Protein Information: urocortin; prepro-urocortin; urocortin, preproprotein
• UniProt Protein Name: Urocortin
• Protein Family: Urocortin
• UniProt Gene Name: UCN
• UniProt Entry Name: UCN1_HUMAN

NCBI Description

This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. [provided by RefSeq, Jul 2008]

Uniprot Description

UCN: Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta. Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 2p23.3

Cellular Component: dendrite; extracellular region; perikaryon; nerve terminal

Molecular Function: corticotropin-releasing hormone receptor 1 binding; neuropeptide hormone activity; histone deacetylase inhibitor activity; protein binding; corticotropin-releasing hormone receptor 2 binding

Biological Process: regulation of synaptic transmission, glutamatergic; positive regulation of translation; negative regulation of hormone secretion; drinking behavior; positive regulation of collagen biosynthetic process; response to glucocorticoid stimulus; response to pain; negative regulation of cell size; female pregnancy; pancreatic juice secretion; positive regulation of vasodilation; negative regulation of appetite; response to estradiol stimulus; positive regulation of adrenocorticotropic hormone secretion; sensory perception of sound; neuropeptide signaling pathway; positive regulation of cAMP biosynthetic process; negative regulation of blood pressure; inflammatory response; associative learning; neurite development; negative regulation of histone deacetylation; activation of protein kinase A; positive regulation of interleukin-6 production; social behavior; positive regulation of cell growth; positive regulation of peptidyl-serine phosphorylation; positive regulation of vascular permeability; G-protein coupled receptor protein signaling pathway; aerobic respiration; response to oxidative stress; positive regulation of DNA replication; negative regulation of apoptosis