Immunohistochemistry (IHC)
(Anti-CYP39A1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.)
Rabbit anti-Human, Mouse CYP39A1 Polyclonal Antibody | anti-CYP39A1 antibody
Rabbit Polyclonal (IgG) to Human CYP39A1
Immunohistochemistry (IHC)
(Anti-CYP39A1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.)
Immunohistochemistry (IHC)
(Anti-CYP39A1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.)
Immunofluorescence (IF)
(Immunofluorescence of A549 cells, using Cytochrome P450 39A1 Antibody. The picture on the right is treated with the synthesized peptide.)
Immunofluorescence (IF)
(Immunofluorescence of A549 cells, using Cytochrome P450 39A1 Antibody. The picture on the right is treated with the synthesized peptide.)
Western Blot (WB)
(Western blot of extracts from LOVO/HUVEC cells, using Cytochrome P450 39A1 Antibody. The lane on the right is treated with the synthesized peptide.)
Western Blot (WB)
(Western blot of extracts from LOVO/HUVEC cells, using Cytochrome P450 39A1 Antibody. The lane on the right is treated with the synthesized peptide.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is involved in the conversion of cholesterol to bile acids. Its substrates include the oxysterols 25-hydroxycholesterol, 27-hydroxycholesterol and 24-hydroxycholesterol. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Description
CYP39A1: Involved in the bile acid metabolism. Has a preference for 24-hydroxycholesterol, and converts it into a 7-alpha- hydroxylated product. Belongs to the cytochrome P450 family.
Protein type: Lipid Metabolism - primary bile acid biosynthesis; Oxidoreductase; Endoplasmic reticulum; EC 1.14.13.99
Chromosomal Location of Human Ortholog: 6p12.3
Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle
Molecular Function: 24-hydroxycholesterol 7alpha-hydroxylase activity; iron ion binding; heme binding; oxysterol 7-alpha-hydroxylase activity; steroid 7-alpha-hydroxylase activity
Biological Process: bile acid biosynthetic process; bile acid metabolic process; xenobiotic metabolic process; bile acid catabolic process; digestion; cholesterol catabolic process; sterol metabolic process
Research Articles on CYP39A1
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Product Notes
The CYP39A1 cyp39a1 (Catalog #AAA243872) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Polyclonal (IgG) to Human CYP39A1 reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CYP39A1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA). ELISA (1:10000), IF (1:100 - 1:500), IHC-P (1:100), WB (1:500 - 1:1000). Researchers should empirically determine the suitability of the CYP39A1 cyp39a1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CYP39A1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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